211105-00-9

Upstream product

• 32454-24-3 2-methyl-2-p-tolyl-propionic acid ethyl ester 
• 2094-98-6 1,1'-azobis (cyclohexanecarbonitrile) 

Downstream Products

• 574759-45-8 2-(4-{[(3-tert-butoxycarbonylmethoxy-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenyl)-2-methyl-propionic acid ethyl ester 
• 174483-06-8 ethyl 4-[4[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetate 
• 207301-64-2 2-[4-(3-[1,3]Dioxolan-2-yl-1-hydroxy-propyl)-phenyl]-2-methyl-propionic acid ethyl ester 
• 207301-40-4 2-[4-(3-[1,3]Dioxolan-2-yl-propionyl)-phenyl]-2-methyl-propionic acid ethyl ester 
• 83799-24-0 fexofenadine 
• 52787-37-8 2-(4-Formyl-phenyl)-2-methyl-propionic acid ethyl ester 

Relevant academic research and scientific papers

Metabolites of (3-[[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid

The present invention relates to metabolites of (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid.

Synthesis of terfenadine and derivatives

Processes for preparing compounds having the general formula: STR1 wherein R1a is protected carboxy, carboxy, hydroxymethyl, protected hydroxymethyl, or methyl are disclosed. Processes of the invention begin with a starting material of the general formula II STR2 and elaborate the product by reductive amination of an aldehyde of formula IVa STR3 with α,α-diphenyl-4-piperidinemethanol.

An efficient and facile synthesis of racemic and optically active fexofenadine

In efficient and practical method for the synthesis of racemic and optically active (96% ee) fexofenadine is described. The key racemic or optically active lactol intermediate 2 is prepared from readily available tolyl derivative 3.