211105-93-0Relevant academic research and scientific papers
Enantioselective 1,3-dipolar cycloadditions of diazoacetates with electron-deficient olefins
Sibi, Mukund P.,Stanley, Levi M.,Soeta, Takahiro
, p. 1553 - 1556 (2008/02/04)
Equation presented A general strategy for highly enantioselective 1,3-dipolar cycloaddition of diazoesters to β-substituted, α-substituted, and α,β-disubstituted α,β-unsaturated pyrazolidinone imides is described. Cycloadditions utilizing less reactive α,β-disubstituted dipolarophiles require elevated reaction temperatures, but still provide the corresponding pyrazolines with excellent enantioselectivities. Finally, an efficient synthesis of (-)-manzacidin A employing this cycloaddition methodology as a key step is illustrated.
