211116-49-3

Upstream product

• 92525-59-2 1,4-dioxaspiro[4.5]dec-7-ene-8-carboxylic acid 
• 72445-22-8 1,4-dioxaspiro[4.5]dec-7-ene-8-carbaldehyde 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 211116-82-4 C₂₁H₂₁N₃O₃S 
• 142613-67-0 (R)-(+)-1'-benzyl-1',2'-dihydro-2'-oxospiro[1,4-dioxaspiro[4.5]dec-6-ene-8,3'-3'H-indole] 
• 142613-66-9 (S)-(-)-1'-benzyl-1',2'-dihydro-2'-oxospiro[1,4-dioxaspiro[4.5]dec-6-ene8,3'-3'H-indole] 
• 142613-61-4 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid (2-iodo-phenyl)-methyl-amide 
• 142613-79-4 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid benzyl-(2-iodo-phenyl)-amide 
• 142613-78-3 1,4-Dioxa-spiro[4.5]dec-7-ene-8-carboxylic acid (2-iodo-phenyl)-(2-trimethylsilanyl-ethoxymethyl)-amide 

Relevant academic research and scientific papers

Catalytic asymmetric synthesis of quaternary carbon centers. Exploratory investigations of intramolecular heck reactions of (E)-α,β-unsaturated 2-haloanilides and analogues to form enantioenriched spirocyclic products

The effect of chiral diphosphine structure, method of catalyst generation, reaction solvent, and HI scavenger on the formation of enantioenriched 3,3-disubstituted 2-oxindole 5 from asymmetric Heck cyclization of 4 was studied (eq 1). Depending upon wheth