21113-93-9Relevant academic research and scientific papers
Cyclopentanoids by uncatalyzed intramolecular carbonyl ene (ICE) reaction of α-keto esters
Tymann, David,Klueppel, Andre,Hiller, Wolf,Hiersemann, Martin
, p. 4062 - 4065 (2014)
The uncatalyzed intramolecular carbonyl ene (ICE) reaction of substituted ε,ζ-unsaturated α-keto esters to terpenoid-related building blocks has been studied. We found a beneficial effect of a silyl substituent at the ene segment on the kinetics of the ICE reaction. A generalizable and scalable synthesis of ε,ζ-unsaturated α-keto esters from allylic alcohols was developed.
