211184-90-6

Usage

Functional group

Acyl chloride A functional group consisting of a carbonyl center (C=O) bonded to a chlorine atom (Cl).

Usage

Organic synthesis reagent Commonly used as a key reagent in the preparation of various pharmaceuticals, agrochemicals, and other organic compounds.

Applications

Production of dyes, perfumes, and chemicals Utilized in the manufacturing of dyes, perfumes, and other chemical products.

Structure

4-methylphenoxy group attached to a propanoyl chloride group The compound's structure features a 4-methylphenoxy group connected to a propanoyl chloride group.

Starting material

Production of esters and amides Frequently used as a starting material in the synthesis of various esters and amides.

Reactivity

Highly reactive Due to the presence of the acyl chloride functional group, the compound is highly reactive and requires careful handling and storage.

Upstream product

• 22504-83-2 2-(4-methylphenoxy)propanoic acid 
• 1121-70-6 sodium 4-methylphenoxide 

Downstream Products

• 1401223-40-2 (S)-N-isopropyl-N-((3-(pyridine-3-yl)-1,2,4-oxadiazol-5-yl)methyl)-2-(p-tolyloxy)propanamide 
• 1401223-41-3 (R)-N-isopropyl-N-((3-(pyridine-3-yl)-1,2,4-oxadiazol-5-yl)methyl)-2-(p-tolyloxy)propanamide 
• 1374762-77-2 N-ethyl-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)propanamide 
• 1048953-52-1 N-(2-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydro-pyrimidin-1(6H)-yl)phenyl)-2-(para-tolyloxy)propanamide 

Relevant academic research and scientific papers

Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents

The paper presents the activity trends for a novel series of phenoxyacetyl amides as human TRPM8 receptor agonists. This series encompasses in vitro activity values ranging from the micromolar to the picomolar levels. Sensory evaluation of these molecules highlights their relevance as cooling agents for oral applications. The positive outcome of the complete evaluation of N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)-2-(p-tolyloxy)acetamide resulted in its approval for Generally Recognized As Safe (GRAS) status by the Flavor & Extract Manufacturer Association (FEMA) as FEMA 4809.

PROTEASOME CHYMOTRYPSIN-LIKE INHIBITION USING PI-1833 ANALOGS

Focused library synthesis and medicinal chemistry on an oxadiazole- isopropylamide core proteasome inhibitor provided the lead compound that strongly inhibits CT-L activity. Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. Only para-substitution in the A-ring was important to maintain potent CT-L inhibitory activity. Hydrophobic residues in the A-ring?s para-position and meta-pyridyl group at the B- ring significantly improved inhibition. The meta-pyridyl moiety improved cell permeability. The length of the aliphatic chain at the para position of the A-ring is critical with propyl yielding the most potent inhibitor, whereas shorter (i.e. ethyl, methyl or hydrogen) or longer (i.e. butyl, propyl and hexyl) chains demonstrating progressively less potency. Introduction of a stereogenic center next to the ether moiety (i.e. substitution of one of the hydrogens by methyl) demonstrated chiral discrimination in proteasome CT-L activity inhibition (the S-enantiomer was 35-40 fold more potent than the R-enantiomer)

Synthesis of N- 2-pyrrolidinone as antimicrobial agent

Several N- 2-pyrrolidinones have been synthesised and screened for their antibacterial and antifungal activities. their structures have been elucidated on the basis of elemental analysis and spectral data.