211303-82-1

Upstream product

• 154318-75-9 4-tert-butylphenyl triflate 
• 762-72-1 allyl-trimethyl-silane 
• 943-27-1 4'-t-butylacetophenone 
• 98-54-4 para-tert-butylphenol 

Downstream Products

• 1009632-32-9 C₂₅H₃₀O₂ 
• 10103-06-7 2,3-dimethoxynaphthalene 
• 1009632-18-1 C₂₄H₂₈ 
• 1009632-61-4 C₂₄H₂₈ 
• 91-57-6 2-Methylnaphthalene 
• 1009632-65-8 C₂₄H₂₈O 
• 1009632-23-8 C₂₄H₂₈O 
• 93-04-9 2-Methoxynaphthalene 
• 269-43-2 naphtho<2,3-d>-1,3-dioxole 
• 1009632-38-5 C₂₄H₂₆O₂ 
• 1380232-88-1 1-(tert-butyl)-4-(4,4,4-trifluorobut-1-en-2-yl)benzene 
• 1421842-38-7 (2-(4-tert-butylphenyl)allyl)(trifluoromethyl)sulfane 

Relevant academic research and scientific papers

Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond-Donor Catalysis

We report a chiral-squaramide-catalyzed enantio- and diastereoselective synthesis of α-allyl amino esters. The optimized protocol provides access to N-carbamoyl-protected amino esters via nucleophilic allylation of readily accessible α-chloro glycinates. A variety of useful α-allyl amino esters were prepared, including crotylated products bearing vicinal stereocenters that are inaccessible through enolate alkylation, with high enantioselectivity (up to 97% ee) and diastereoselectivity (>10:1). The reactions display first-order kinetic dependence on both the α-chloro glycinate and the nucleophile, consistent with rate-limiting C-C bond formation. Computational analysis of the uncatalyzed reaction predicts an energetically inaccessible iminium intermediate, and a lower energy concerted SN2 mechanism.

Pd-Catalyzed C(sp3)-C(sp2) cross-coupling of Y(CH2SiMe3)3(THF)2 with vinyl bromides and triflates

Pd-Catalyzed C(sp3)-C(sp2) cross-coupling of Y(CH2SiMe3)3(THF)2 with vinyl bromides and triflates has been developed for efficient synthesis of various allyltrimethylsilanes. The cross-coupling reaction was conducted at room temperature with low catalyst loading of either Pd(PPh3)4 or Pd(PPh3)2Cl2, and exhibited high efficiency and a broad substrate scope. In combination with the cross-coupling by the Lewis-acid catalyzed Hosomi-Sakurai reaction, a novel three-component one-pot cascade reaction was then accomplished to deliver homoallylic alcohols and ethers with high regioselectivity and diastereoselectivity. The three-component reaction defined the yttrium complex as a novel one-carbon synthon, which could either trigger bifunctionalization of alkenes or link two electrophiles and would find applications in organic synthesis.

Copper-catalyzed trifluoromethylation of allylsilanes

CF3 on Csp3: Trifluoromethylation of allylsilane derivatives was accomplished through the use of CuI and Togni's reagent (1) under mild conditions. The reaction of allylsilanes without a substituent in the 2-position gave vinylsilane derivative

Highly Regioselective Palladium-Catalyzed Internal Arylation of Allyltrimethylsilane with Aryl Triflates

Highly regioselective ligand-controlled Heck-arylation reactions of allyltrimethylsilane, delivering branched β-products, were performed in moderate to good yields. The high preference for internal over terminal double-bond arylation suggests a contributi