211315-28-5

Upstream product

• 211315-27-4 N-2-(4-(N',N'-dibenzylamino)phenyl)propyl 2-propanesulfonamide 

Downstream Products

• 211313-57-4 N-2-(4-N-(benzamido)phenyl)propyl 2-propanesulfonamide 
• 211313-60-9 N-{2-[4-(4-fluorobenzoylamino)phenyl]propyl}propane-2-sulfonamide 
• 1093845-60-3 N-{2-[4-(4-nitrobenzoylamino)phenyl]propyl}propane-2-sulfonamide 
• 211313-51-8 LY₃₉₅₁₅₃ 

Relevant academic research and scientific papers

N-2-(4-N-(4-[18F]Fluorobenzamido)phenyl)-propyl-2- propanesulphonamide: Synthesis and radiofluorination of a putative AMPA receptor ligand

Arylpropylsulphonamides are in the focus of research as α-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid (AMPA) receptor ligands. A new fluorine-18-labelled potentiator of AMPA receptors was synthesized as a potential radiotracer for cerebral imaging w

Sulphonamide derivatives

Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formulaR1—L—NHSO2R2??Iin whichR1 represents an unsubstituted or substituted aromatic or heteroaromatic group;R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; andL represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring;and pharmaceutically acceptable salts thereof.Also disclosed are compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.

Sulphonamide derivatives

The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.