21133-52-8

Basic information

• Product Name: Dihydrogalanthamine
• Synonyms: Dihydrogalanthamine;6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,7,8,9,10,11,12-octahydro-3-methoxy-11-methyl-,(4aS,6S,8aR)-;Galanthamine, 1,2-dihydro-;Galanthamine, dihydro-;(4aS,8aS)-3-Methoxy-11-methyl-4aα,5,7,8,9,10,11,12-octahydro-6H-benzofuro[3a,3,2-ef][2]benzoazepine-6β-ol;(4aS,8aS)-4a,5,7,8,9,10,11,12-Octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6β-ol;(8aS)-3-Methoxy-5,6,7,8,9,10,11,12-octahydro-11-methyl-4aαH-benzofuro[3a,3,2-ef][2]benzazepine-6β-ol;(4aS,6S,8aS)-4a,5,7,8,9,10,11,12-Octahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
• CAS NO: 21133-52-8
• Molecular Formula: C17H23NO3
• Molecular Weight: 289.36942
• Product Categories: Alkaloids;Chiral Reagents;Heterocycles;Inhibitor;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 21133-52-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 122-124 ºC
• Boiling Point: 436.4°C at 760 mmHg
• Flash Point: 217.7°C
• Appearance: /
• Density: 1.25
• Vapor Pressure: 2.17E-08mmHg at 25°C
• Refractive Index: 1.614
• PKA: 14.77±0.20(Predicted)
• CAS DataBase Reference: Dihydrogalanthamine(CAS DataBase Reference)
• NIST Chemistry Reference: Dihydrogalanthamine(21133-52-8)
• EPA Substance Registry System: Dihydrogalanthamine(21133-52-8)

Safety Data

• Hazardous Substances Data: 21133-52-8(Hazardous Substances Data)

Usage

Description

Dihydrogalanthamine is a minor alkaloid derived from the plant Lycoris radiata, which is known for its highly efficient, selective, and sensitive properties as an acetylcholinesterase inhibitor. It is an analog of Galanthamine (G188500) and has potential applications in various industries due to its unique characteristics.

Uses

Used in Pharmaceutical Industry:
Dihydrogalanthamine is used as a pharmaceutical agent for its potent acetylcholinesterase inhibitory properties. This makes it a valuable compound in the development of treatments for conditions related to the overactivity of acetylcholinesterase, such as Alzheimer's disease and other cognitive disorders.
Used in Research and Development:
As a highly efficient, selective, and sensitive acetylcholinesterase inhibitor, Dihydrogalanthamine is used in research and development for the study of cholinergic systems and the development of new drugs targeting these systems. Its analog nature to Galanthamine (G188500) also makes it a useful tool for comparative studies and the development of novel therapeutic strategies.
Used in Drug Delivery Systems:
Dihydrogalanthamine's properties as an acetylcholinesterase inhibitor can be leveraged in the development of drug delivery systems, particularly for targeted therapies. These systems can be designed to improve the bioavailability, delivery, and therapeutic outcomes of Dihydrogalanthamine, enhancing its efficacy in treating conditions related to acetylcholinesterase overactivity.

InChI:InChI=1/C17H23NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-4,12,14,19H,5-10H2,1-2H3/t12-,14-,17-/m0/s1