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211364-63-5

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211364-63-5 Usage

Description

3-N-Carboxylic Acid 1-β-D-Glucuronide-[4-(Methyl)phenyl]carbaMate Ester Doxorubicin, also known as Doxorubicin, is an anthracycline antibiotic derived from the bacterium Streptomyces peucetius. It is characterized by its potent anti-cancer properties and is widely used in the treatment of various types of cancer. The molecule consists of a glucuronide prodrug structure, which enhances its solubility and bioavailability, allowing for more effective delivery to cancer cells.

Uses

Used in Oncology:
3-N-Carboxylic Acid 1-β-D-Glucuronide-[4-(Methyl)phenyl]carbaMate Ester Doxorubicin is used as an anticancer agent for the treatment of a wide range of cancers. It is particularly effective against solid tumors, such as breast cancer, ovarian cancer, thyroid cancer, and certain types of lung, gastric, and pancreatic cancers. The drug works by intercalating into DNA, inhibiting topoisomerase II, and generating free radicals, which ultimately leads to the disruption of DNA replication and transcription, causing cell death.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 3-N-Carboxylic Acid 1-β-D-Glucuronide-[4-(Methyl)phenyl]carbaMate Ester Doxorubicin is used as a component in the development of novel drug delivery systems. These systems aim to improve the drug's solubility, bioavailability, and targeted delivery to cancer cells, thereby enhancing its therapeutic efficacy and reducing side effects. Various carriers, such as liposomes, nanoparticles, and polymeric micelles, have been explored for the encapsulation and controlled release of Doxorubicin.
Used in Research and Development:
3-N-Carboxylic Acid 1-β-D-Glucuronide-[4-(Methyl)phenyl]carbaMate Ester Doxorubicin is also utilized in the field of biomedical research as a model compound for studying the mechanisms of action, drug resistance, and the development of new anticancer agents. Its unique chemical structure and potent anti-cancer activity make it an invaluable tool for understanding the complex interactions between chemotherapeutic drugs and cancer cells, as well as for designing more effective and targeted cancer treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 211364-63-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,1,3,6 and 4 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 211364-63:
(8*2)+(7*1)+(6*1)+(5*3)+(4*6)+(3*4)+(2*6)+(1*3)=95
95 % 10 = 5
So 211364-63-5 is a valid CAS Registry Number.

211364-63-5Upstream product

211364-63-5Downstream Products

211364-63-5Relevant articles and documents

Esters Of Glucuronide Prodrugs Of Anthracyclines And Method Of Preparation And Use In Tumor-Selective Chemotherapy

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Page/Page column 16, (2009/09/25)

The invention relates to novel esters and in particular to some novel esters of glucuronide prodrugs of anthracyclines having tunable water-solubility, their synthesis and use in tumor-selective chemotherapy. It appeared that in the final step in the synt

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