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R18 trifluoroacetate is a nonphosphorylated peptide that was originally identified as a high-affinity 14-3-3 ligand through phage display. It is known for its ability to interact with specific proteins and has been utilized in various applications across different industries.

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  • L-Proline,L-prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-a-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-a-aspartyl-L-leucyl-L-a-glutamyl-L-alanyl-L-asparaginyl-L-methionyl-L-cystein

    Cas No: 211364-78-2

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  • 211364-78-2 Structure
  • Basic information

    1. Product Name: R18
    2. Synonyms: R18;L-Prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-a-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-a-aspartyl-L-leucyl-L-a-glutamyl-L-alanyl-L-asparaginyl-L-methionyl-L-cysteinyl-L-leucyl-L-proline trifluoroacetate;PHCVPRDLSWLDLEANMCLP trifluoroacetate;Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-T;R18 trifluoroacetate
    3. CAS NO:211364-78-2
    4. Molecular Formula: C101H157N27O29S3
    5. Molecular Weight: 2309.68578
    6. EINECS: N/A
    7. Product Categories: Caspases/Apoptosis
    8. Mol File: 211364-78-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: white to off-white/
    5. Density: 1.50±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Desiccate at -20°C
    8. Solubility: N/A
    9. CAS DataBase Reference: R18(CAS DataBase Reference)
    10. NIST Chemistry Reference: R18(211364-78-2)
    11. EPA Substance Registry System: R18(211364-78-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 211364-78-2(Hazardous Substances Data)

211364-78-2 Usage

Uses

Used in Plant Biology Research:
R18 is used as a research tool for studying the effect of R18 on CBF3 degradation in planta. This application is particularly relevant for understanding the role of Super:C-repeat-binding factors (CBFs) and Myc in plant development and stress responses.
Used in Pharmaceutical and Biochemical Applications:
As a high-affinity 14-3-3 ligand, R18 is used in the development of drugs and biochemical compounds targeting the 14-3-3 protein family. These proteins are involved in various cellular processes, including signal transduction, apoptosis, and cell cycle regulation, making them important therapeutic targets for various diseases.
Used in Drug Delivery Systems:
R18's high-affinity interaction with 14-3-3 proteins can be leveraged in the development of novel drug delivery systems. These systems can potentially improve the delivery, bioavailability, and therapeutic outcomes of drugs targeting the 14-3-3 protein family.

Biochem/physiol Actions

C-repeat-binding factors (CBFs) protein -Myc?transgenic plants, R18 is capable of reducing the degradation of?CBF1 and CBF3.

Check Digit Verification of cas no

The CAS Registry Mumber 211364-78-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,1,3,6 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 211364-78:
(8*2)+(7*1)+(6*1)+(5*3)+(4*6)+(3*4)+(2*7)+(1*8)=102
102 % 10 = 2
So 211364-78-2 is a valid CAS Registry Number.

211364-78-2 Well-known Company Product Price

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  • Sigma

  • (SML0108)  R18 trifluoroacetate  ≥98% (HPLC)

  • 211364-78-2

  • SML0108-1MG

  • 1,843.92CNY

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