211385-74-9Relevant academic research and scientific papers
Anti-AIDS agents 31. Synthesis and anti-HIV activity of 4-substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) thiolactone analogs
Yang, Zheng-Yu,Xia, Yi,Xia, Peng,Cosentino, L. Mark,Lee, Kuo-Hsiung
, p. 1483 - 1486 (1998)
Four DCK-thiolactone analogs (3-6) were synthesized asymmetrically and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. Based on the functionality on the thiolactone-coumarin nucleus, activity was in the order: methyl > H > propyl > benzyl. 4-Methyl-3',4'-di- O-(-)-camphanoyl-(+)-cis-khelthiolactone (4) exhibited extremely potent anti- HIV activity with EC50 and therapeutic index values of 0.00718 μM and > 21,300, respectively.
