21141-02-6

Upstream product

• 2386-25-6 2,4-dimethyl-3-acetylpyrrole 
• 123-63-7 paracetaldehyde 
• 29917-12-2 Isonitrosoacetylacetone 
• 123-54-6 acetylacetone 
• 64-17-5 ethanol 
• 1500-92-1 2,4-diacetyl-3,5-dimethyl-1H-pyrrole 

Relevant academic research and scientific papers

Alkylation process

Substituted pyrrole compounds, such as 3-ethyl-4-methyl-5-carbethoxy pyrrole, 2,4-dimethyl-3-acetyl pyrrole and 2-methyl-5-carboxy pyrrole-4-propionic acid diethyl ester, are alkylated in a single step by reaction with an aldehyde or ketone in the presence of both an acid condensing agent such as hydriodic acid and a compatible reducing agent such as metallic zinc or stannous chloride. Suitable carbonyl reactants include formaldehyde, paraldehyde, isobutyraldehyde, acetone, cyclohexanone and methyl-isobutyl ketone. This application is a continuation application of U.S. application Ser. No. 281,624 filed Aug. 18, 1972, now abandoned, which is a continuation-in-part application of U.S. application Ser. No. 832,001, filed June 10, 1969, now abandoned.