21152-87-4Relevant academic research and scientific papers
Synthesis of C-C bonded dimeric steroids by olefin metathesis
Edelsztein, Valeria C.,Di Chenna, Pablo H.,Burton, Gerardo
, p. 3615 - 3623 (2009)
Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (2.5 mol %). Due to the bulky nature of the steroidal skeleton the more favorable E-dimers were formed as the sole or major products depending on the linker length.
Amino steroids as antimalarial agents
Sharma, Upasana,Srivastava, Kumkum,Puri, Sunil K.,Singh, Chandan
, p. 326 - 334 (2008/12/22)
Using easily accessible deoxycholic acid as the starting material, amino compounds 8a-e and 9a-c were prepared and screened against P. falciparum in vitro. Amino steroid 8d was the most active of the series with a minimum inhibiting concentration (MIC) of
A simple efficient synthesis of [23,24]-13C2-labeled bile salts as NMR probes of protein-ligand interactions
Tochtrop, Gregory P.,DeKoster, Gregory T.,Cistola, David P.,Covey, Douglas F.
, p. 433 - 435 (2007/10/03)
The synthesis of [23,24]-13C2-labeled bile salts is achieved through a steroidal side chain degradation and isotopic regeneration strategy. Three common bile acids were degraded to the corresponding C22 aldehyde by an oxidative decarboxylation followed by ozonolysis. The side chain was subsequently regenerated via a Horner-Emmons reaction using an ylide generated from 13C2-labeled bromoacetic acid. These compounds were used as probes of protein-bile salt interactions using two- and three-dimensional NMR techniques.
