21156-84-3

Basic information

• Product Name: 1-Methyl-4-(hydroxyethyl)piperidine
• Synonyms: 1-Methyl-4-(hydroxyethyl)piperidine;1-Methyl-4-(hydroxyethyl)...;2-(1-methyl-4-piperidinyl)ethanol(SALTDATA: FREE);2-(1-Methylpiperidin-4-yl)ethanol;2-(1-Methylpiperidino)ethanol;2-(1-methylpiperidin-4-yl)ethan-1-ol;1-Methyl-4-piperidineethanol;2-(1-Methyl-4-piperidyl)ethanol
• CAS NO: 21156-84-3
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.22668
• Mol File: 21156-84-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 209.681 °C at 760 mmHg
• Flash Point: 79.936 °C
• Appearance: colorless liquid
• Density: 0.939 g/cm³
• Vapor Pressure: 0.046mmHg at 25°C
• Refractive Index: 1.465
• PKA: 15.10±0.10(Predicted)
• CAS DataBase Reference: 1-Methyl-4-(hydroxyethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-(hydroxyethyl)piperidine(21156-84-3)
• EPA Substance Registry System: 1-Methyl-4-(hydroxyethyl)piperidine(21156-84-3)

Safety Data

• Hazardous Substances Data: 21156-84-3(Hazardous Substances Data)

Usage

General Description

1-Methyl-4-(hydroxyethyl)piperidine is a chemical compound with the molecular formula C9H19NO. It is a piperidine derivative that contains a methyl group and a hydroxyethyl group attached to the piperidine ring. 1-Methyl-4-(hydroxyethyl)piperidine is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. It has been studied for its potential use in the treatment of neurological disorders, and it has also been investigated for its role as a chiral ligand in asymmetric catalysis. Additionally, 1-Methyl-4-(hydroxyethyl)piperidine has been identified as a key component in the synthesis of various intermediate compounds for organic chemistry applications. Overall, this chemical has shown potential for diverse synthetic and medicinal applications.

InChI:InChI=1/C8H17NO/c1-9-5-2-8(3-6-9)4-7-10/h8,10H,2-7H2,1H3

Upstream product

• 118764-00-4 N-methylquinuclidinium hydroxide 

Downstream Products

• 16897-67-9 4-(3,3-diphenyl-propyl)-1-methyl-piperidine 
• 1159928-76-3 2-(1-methylpiperidin-4-yl)ethyl 4-(4-methylphenyl)piperazine-1-carboxylate 
• 1158803-82-7 (S)-2-(l1-methylpiperidin-4-yl)ethyl 2-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-fluorophenyl)acetate 
• 753005-95-7 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-[2-(1-methylpiperidin-4-yl)ethoxy]quinoline-3-carbonitrile 
• 622368-88-1 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[2-(1-methylpiperidin-4-yl)ethoxy]-3-quinolinecarbonitrile 

Relevant articles and documents

Ketene reactions with tertiary amines

Tertiary amines react rapidly and reversibly with arylketenes in acetonitrile forming observable zwitterions, and these undergo amine catalyzed dealkylation forming N,N-disubstituted amides. Reactions of N- methyldialkylamines show a strong preference for methyl group loss by displacement, as predicted by computational studies. Loss of ethyl groups in reactions with triethylamine also occur by displacement, but preferential loss of isopropyl groups in the phenylketene reaction with diisopropylethylamine evidently involves elimination. Quinuclidine rapidly forms long-lived zwitterions with arylketenes, providing a model for catalysis by cinchona and related alkaloids in stereoselective additions to ketenes.