21156-91-2Relevant academic research and scientific papers
Expanding the regioselective enzymatic repertoire: Oxidative mono-cleavage of dialkenes catalyzed by Trametes hirsuta
Paul, Caroline E.,Rajagopalan, Aashrita,Lavandera, Ivan,Gotor-Fernandez, Vicente,Kroutil, Wolfgang,Gotor, Vicente
supporting information; experimental part, p. 3303 - 3305 (2012/04/23)
The first report of a biocatalytic regioselective oxidative mono-cleavage of dialkenes was successfully achieved employing a cell-free enzyme preparation from Trametes hirsuta at the expense of molecular oxygen. Selected reactions were performed on a preparative scale affording high to excellent conversions and chemoselectivities. The Royal Society of Chemistry 2012.
Chemical synthesis and biological evaluation of second-generation palmerolide a analogues
Ravu, Vengala Rao,Leung, Gulice Y. C.,Lim, Chek Shik,Ng, Sin Yee,Sum, Rong Ji,Chen, David Y.-K.
, p. 463 - 468 (2011/04/17)
In this communication, second-generation analogues of palmerolide A, a recently reported cytotoxic agent against melanoma cancer cells, were rationally designed, synthesized, and biologically evaluated. Structural variations of the enamide side chain and the C1-C8 segment of palmerolide A revealed a narrow structure-activity relationship window of the newly synthesized compounds. In addition, mechanistic and pharmacological studies were performed to assess the therapeutic potential of palmerolide A. Synthesis and biological evaluation of second-generation palmerolide A analogues are reported. This study focused on further modification of the enamide side chain, and the C1-C8 carbon backbone of palmerolide A. Structure-activity relationship, mechanistic, and pharmacological investigations of the palmerolide compounds pave the foundation for the ensuing in vivo studies.
