211568-07-9

Upstream product

• 112897-97-9 (E)-3-(3,4-difluorophenyl)acrylic acid 
• 26386-88-9 diphenyl phosphoryl azide 

Downstream Products

• 444898-79-7 6,7-difluoro-2H-isoquinolin-1-one 
• 936366-62-0 C₉H₅F₂NO 
• 936366-22-2 E-{(5-chloro-benzo[b]thiophen-3-yl)-[2-(3,4-difluoro-phenyl)-vinylcarbamoyl]-methyl}-methyl-phosphinic acid 
• 936366-54-0 {(5-chloro-benzo[b]thiophen-3-yl)-[2-(3,4-difluoro-phenyl)-vinylcarbamoyl]-methyl}-methyl-phosphonic acid 
• 936366-48-2 C₂₂H₂₁ClF₂NO₃PS 
• 936366-47-1 C₂₂H₂₂ClF₂N₂O₃P 
• 936366-46-0 {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester 
• 936366-41-5 C₂₂H₂₁ClF₂NO₄PS 

Relevant academic research and scientific papers

SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME

The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.

Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase

A series of β-carboxamido-phosphon(in)ic acids (2) was identified as a new structural motif for obtaining potent inhibitors of human mast cell chymase. For example, 1-naphthyl derivative 5f had an IC50 value of 29 nM and (E)-styryl derivative 6

Novel inhibitors of chymase

The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.

Synthesis of novel substituted isoquinolones

A series of novel substituted isoquinolones have been synthesised. This has been achieved by two routes, either Curtius rearrangment of cinnamic acids or via an isoquinoline N-oxide.