211571-56-1Relevant academic research and scientific papers
Resolution of fluorinated aminomethanphosphonic acids catalysed by penicillin g acylase - III
Vaubaillon,Giraud,Rabiller,Gruss,Haas,Haegele
, p. 177 - 183 (1997)
In this work, we have used Penicillin G acylase (EC 3.5.1.11) from E. coli to resolve kinetically four fluorinated aminomethanphosphonic acids : 1: 1-trifluoromethyl-, 2:1-p-fluorophenyl-, 3:1-m-fluorophenyl-, 4: 1-p-trifluoromethylphenyl-1-aminomethanphosphonic acids. This enzyme catalyses enantioselectively the hydrolysis of the N-phenylacetylated derivatives of 1-4. The enantiomeric excesses determined via 31P NMR spectra of the diastereomeric Pd(II) complexes of 1-4 were high for each compound studied. Dans ce travail, on a utilise la Penicilline G acylase (EC 3.5.1.11) de E. coli pour effectuer la resolution cinetique de quatre acides aminomethanphosphoniques fluores : acides 1: 1-trifluoromethyl-, 2: 1-p-fluorophenyl-, 3: 1-m-fluorophenyl-, 4: 1-p-trifluoromethylphenyl-1-aminomethanphosphoniques. Cette enzyme catalyse enantioselectivement l'hydrolyse des derives N-phenylacelyles des composes 1-4. Les exces enantiomeriques calcules grace aux spectres RMN du 31P des complexes diastereomeres du Pd(II) des produits 1-4 se sont reveles excellents dans chacun des cas etudies.
