211575-80-3

Upstream product

• 211575-75-6 N-[5'-O-(4,4'-dimethoxytrityl)-3'-amino-3'-deoxythymidin-3'-yl]-O-(3'-O-acetylthymidin-5'-yl)-methanephosphonamidate 
• 439113-14-1 Acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-methylphosphinoyloxymethyl-tetrahydro-furan-3-yl ester 
• 439113-12-9 C₁₉H₃₂N₃O₆P 
• 143526-94-7 3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine 

Relevant academic research and scientific papers

Synthesis of dinucleoside (N3′→MeP5′) methanephosphonamidates

Three different approaches were used for the synthesis of dinucleoside methanephosphonamidates [3′-NH-P(O)(CH3)O-5′], starting from dichloromethylphosphine or dichloromethanephosphonate as the phosphorus-containing moiety. 5′-DMT-3′-amino-3′-deoxythymidine and N(4)-benzoyl-5′-DMT-3′-amino-2′,3′-dideoxycytidine were used as the aminonucleoside precursors and the respective 3′-protected nucleosides (thymidine or N(4)-benzoyl-2′-deoxycytidine) as the 5′-hydroxyl reagents.