211635-35-7Relevant academic research and scientific papers
Cyclooctatetraenes through Valence Isomerization of Cubanes: Scope and Limitations
Houston, Sevan D.,Xing, Hui,Bernhardt, Paul V.,Vanden Berg, Timothy J.,Tsanaktsidis, John,Savage, G. Paul,Williams, Craig M.
, p. 2735 - 2739 (2019/02/07)
The scope and limitations of Eaton's rhodium(I)-catalyzed valence isomerization of cubane to cyclooctatetraene (COT) were investigated in the context of functional group tolerability, multiple substitution modes and the ability of cubane-alcohols to undergo one-pot tandem Ley–Griffith Wittig reactions in the absence of a transition metal catalyst.
Cubanes in medicinal chemistry: Synthesis of functionalized building blocks
Wlochal, Joanna,Davies, Robert D. M.,Burton, Jonathan
, p. 4094 - 4097 (2014/09/29)
A collection of novel, pharmaceutically relevant cubane-containing molecules has been prepared from the commercially available cubane-1,4- dimethylester. A range of synthetic methods have been applied to prepare these cubane building blocks with one or two functional handles to allow easy incorporation into existing medicinal chemistry programs.
Synthesis and preliminary evaluation of (S)-2-(4'-carboxycubyl)glycine, a new selective mGluR1 antagonist
Pellicciari, Roberto,Costantino, Gabriele,Giovagnoni, Emiliano,Mattoli, Luisa,Brabet, Isabelle,Pin, Jean-Philippe
, p. 1569 - 1574 (2007/10/03)
The synthesis and the pharmacological evaluation at metabotropic glutamate receptors of S-2-(4'-carboxy-cubyl)glycine (ACUDA, 9) are described. S-2-(4'-Carboxy-cubyl)glycine is a structurally novel group I selective antagonist for mGluR1 subtype.
