211677-38-2Relevant academic research and scientific papers
Effect of p-substitution of aryl α-D-mannosides on inhibiting mannose-sensitive adhesion of Escherichia coli - Syntheses and testing
Lindhorst, Thisbe K.,Koetter, Sven,Kubisch, Jiri,Krallmann-Wenzel, Ulrike,Ehlers, Stefan,Kren, Vladimir
, p. 1669 - 1674 (1998)
A series of p-substituted aryl α-D-mannosides was synthesized and tested with regard to their inhibitory capacity in the hemagglutination of guinea pig erythrocytes by type 1 fimbriated Escherichia coli. Synthesis of the bivalent, phenyl-linked mannoside cluster 10 was complicated by orthoester formation during the glycosylation reaction. Surprisingly, the inhibitory potency of 10 was lower than that of p-nitrophenyl α-D-mannoside (1) and this is an important finding for the further design of clustered ligands.
