211677-99-5

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 176095-70-8 2-(trimethylsilyl)ethyl 2,3-di-O-benzoyl-β-D-galactopyranoside 

Downstream Products

• 211678-02-3 2-(trimethylsilyl)ethyl (2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->4)-6-azido-2,3-di-O-benzoyl-6-deoxy-β-D-galactopyranoside 
• 211678-03-4 (2R,3R,4R,5R,6R)-6-Azidomethyl-2-(2-trimethylsilanyl-ethoxy)-5-((2R,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3,4-diol 
• 211678-00-1 2-(trimethylsilyl)ethyl 6-azido-2,3-di-O-benzoyl-6-deoxy-β-D-galactopyranoside 
• 211678-04-5 2-(trimethylsilyl)ethyl (2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-(1->4)-2,3-di-O-benzoyl-6-O-tosyl-β-D-galactopyranoside 

Relevant academic research and scientific papers

Synthesis of some amino and carboxy analogs of galabiose; evaluation as inhibitors of the pilus protein PapG(J)96 from Escherichia coli

The 2'-amino-2'-deoxy, 6-amino-6-deoxy, and 6-carboxy analogs of the reference inhibitor 2(trimethylsilyl)ethyl (α-D-galactopyranosyl)-(1→4)- β-d-galactopyranoside were synthesized and evaluated as inhibitors of the binding of the Escherichia coli-derived pilus protein PapG(J96), using an ELISA assay. The inhibitory efficiencies (K(rel); relative to the reference inhibitor) were: 157, 13, and 8, respectively. The results support the previously proposed combining site model, where the protein carries a negatively charged amino acid residue near HO-2' and HO-6 of the galabioside.