211753-40-1Relevant academic research and scientific papers
Synthesis of nucleosides of pyrido-pyrimidines and their microbial activity
Singh, Gajendra,Swati,Mishra, A. K.,Prakash, L.
, p. 517 - 520 (2007/10/03)
The nucleosides, 4-amino-5, 7-disubstituted-1-pyrido-pyrimidin-2-ones/thiones 6 and 7 and 3,5,7-trisubstituted-1-(β-D-ribofuranosyl>-pyrido pyrimidine-2, 4(3H)-diones 8 have been synthesized from 5,7-disubstituted pyrido--pyrimidin-2(1H)-ones/thiones 3 and 4 and 3,5,7-trisubstituted-1H, 3H-pyridopyrimidine-2,4-diones 5 respectively.The structures of the synthesized nucleosides and their precursors have been established by IR, 1H NMR and elemental analysis.These compounds have been tested for their antibacterial and antifungal activity and are found to be better antibacterial and antifungal agents than their precursors pyridopyrimidines.
