21179-17-9Relevant academic research and scientific papers
8-Hydroxyanthracyclinones from ε-Rhodomycinone
Lin, Horng-jau,Kumar, Virendra,Remers, William A.
, p. 1242 - 1244 (2007/10/02)
ε-Rhodomycinone was converted into 8,9-dehydro-ζ-rhodomycinone, which gave a cis diol with osmium tetroxide and a pair of epimeric epoxides with m-chloroperbenzoic acid.Acid-catalyzed opening of the epoxides gave the corresponding trans diols.In contrast, acid treatment of the trimethyl ethers of these epoxides gave predominantly a lactone and an η-rhodomycinone derivative, with only small amounts of the diols.None of the new rhodomycinones were active against Bacillus subtilis, but 8,9-dehydro-ζ-rhodomycinone was active in the induction of lytic phage in Escherichia coli.
