211803-71-3Relevant academic research and scientific papers
Metal-Free Radical Annulation of Oxygen-Containing 1,7-Enynes: Configuration-Selective Synthesis of (E)-3-((Arylsulfonyl)methyl)-4-Substituted Arylidenechromene Derivatives
Bian, Mouwang,Dai, Lei,Mao, Kaimin,Rong, Liangce,Wang, Chang,Yu, Qiuyu,Zhang, Jinghang
, p. 218 - 224 (2021/01/13)
A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction of oxygen-containing 1,7-enynes with thiosulfonates has been developed. The reaction shows broad substrate scope, wide functional group tolerance, and moderate to excellent yields. Moreover, thiosulfonates were well driven to achieve the bifunctionalization reaction of oxo-1,7-enynes which derived from aliphatic alkynes. In addition, the (E)-configuration of the products was highly controlled by the structure of 1,7-enyne.
Alkylation of terminal alkynes with transient σ-alkylpalladium(II) Complexes: A carboalkynylation route to alkyl-substituted alkynes
Zhou, Ming-Bo,Huang, Xiao-Cheng,Liu, Yan-Yun,Song, Ren-Jie,Li, Jin-Heng
supporting information, p. 1843 - 1846 (2014/03/21)
A mild and general alkylation of terminal alkynes with transient σ-alkylpalladium(II) complexes for assembling alkyl-substituted alkynes is described. This method represents a new way to the use of transient σ-alkylpalladium(II) complexes in organic synthesis through 1,2-carboalkynylation of alkenes.
Rhodium-catalyzed olefin isomerization/enantioselective intramolecular alder-ene reaction cascade
Okamoto, Ryuichi,Okazaki, Eri,Noguchi, Keiichi,Tanaka, Ken
, p. 4894 - 4897 (2011/11/29)
The olefin isomerization/enantioselective intramolecular Alder-ene reaction cascade was achieved by using a cationic rhodium(I)/(R)-BINAP complex as a catalyst. A variety of substituted dihydrobenzofurans and dihydronaphthofurans were obtained from phenol
Palladium-catalyzed cyclization of o-alkynylphenols with allyl carbonates. A regioselective synthesis of 2-substituted-3-allylbenzo[b]furans
Cacchi, Sandro,Fabrizi, Giancarlo,Moro, Leonardo
, p. 741 - 745 (2007/10/03)
2-Substituted-3-allylbenzo[b]furans 3 can be prepared from o-alkynylphenols 1 and allyl carbonates 2 through a palladium-catalyzed O-allylation/cyclization sequence. Two basic procedures have been developed: a stepwise method based on the isolation of O-allyl derivatives 4 and their subsequent cyclization to 3 (procedure A) and a one-pot reaction omitting the isolation of 4 (procedure B). The cyclization of 4 in the presence of the electron-rich sterically-encumbered ligand tris(2,4,6-trimethoxyphenyl)phosphine (ttmpp) exhibits remarkable regioselectivity in that 3-allylbenzofurans in which the benzofuryl unit is bound to the less substituted allyl terminus are formed almost exclusively. Some loss of the stereochemistry of the carbon-carbon double bond is observed.
