211809-39-1Relevant academic research and scientific papers
Synthesis of α,α-disubstituted-α-amino acids by double nucleophilic addition to cyanohydrins
Charette, Andre B.,Gagnon, Alexandre,Janes, Marc,Mellon, Christophe
, p. 5147 - 5150 (1998)
The synthesis of tertiary carbinamines was achieved by the double nucleophilic addition of Grignard reagents to cyanohydrins. Titanium isopropoxide was found to promote the process. In a typical example, the rapid conversion of a carbinamine to the corespondlng α,α-disubstituted- α-amino acid was also demonstrated.
