211816-22-7Relevant academic research and scientific papers
An asymmetric synthesis of ADDA, and ADDA-glycine dipeptide using the ss-lactam synthon method
Cundy, Darren J.,Donohue, Andrew C.,McCarthy, Tom D.
, p. 559 - 567 (2007/10/03)
The paper describes the synthesis of the W-Boc lactam 4, and demonstrates that it is an important intermediate in the synthesis of dipeptide 5 (X = H, n = 0, R = Me), an analogue of the ADDA-GIu dipeptide 3. In addition we have described a mild method for the preparation of the amino acid salt ADDA-HC1, and provided synthetic methods, and full characterisation for the previously 'elusive' free amino acid ADDA.
Towards an asymmetric synthesis of ADDA conjugates
Cundy, Darren J.,Donohue, Andrew C.,McCarthy, Tom D.
, p. 5125 - 5128 (2007/10/03)
In order to develop a general synthesis of ADDA containing peptides, an asymmetric synthesis of the β-lactum 4 and initial investigations into its opening with aminoesters is described.
