211816-41-0Relevant academic research and scientific papers
An asymmetric synthesis of ADDA, and ADDA-glycine dipeptide using the ss-lactam synthon method
Cundy, Darren J.,Donohue, Andrew C.,McCarthy, Tom D.
, p. 559 - 567 (2007/10/03)
The paper describes the synthesis of the W-Boc lactam 4, and demonstrates that it is an important intermediate in the synthesis of dipeptide 5 (X = H, n = 0, R = Me), an analogue of the ADDA-GIu dipeptide 3. In addition we have described a mild method for the preparation of the amino acid salt ADDA-HC1, and provided synthetic methods, and full characterisation for the previously 'elusive' free amino acid ADDA.
Total synthesis of motuporin (nodularin-v)
Bauer, Shawn M.,Armstrong, Robert W.
, p. 6355 - 6366 (2007/10/03)
The serine/threonine phosphatase (protein phosphatase 1 and 2A) inhibitors constitute a biologically and structurally interesting class of natural products. Among this class of inhibitors are cyclic pentapeptides (nodularins) and cyclic heptapeptides (mic
Towards an asymmetric synthesis of ADDA conjugates
Cundy, Darren J.,Donohue, Andrew C.,McCarthy, Tom D.
, p. 5125 - 5128 (2007/10/03)
In order to develop a general synthesis of ADDA containing peptides, an asymmetric synthesis of the β-lactum 4 and initial investigations into its opening with aminoesters is described.
