211819-59-9Relevant academic research and scientific papers
Diastereoselective synthesis of highly substituted five-membered-ring oxygen heterocycles by zirconocene-mediated C - C coupling reactions
Enders, Dieter,Kroll, Manfred,Raabe, Gerhard,Runsink, Jan
, p. 1673 - 1675 (2007/10/03)
As homoenolate equivalents, zirconocene-1-aza-1,3-diene complexes were used for the first time in stereoselective synthesis. By insertion of an unsymmetrical ketone in the Zr-C σ bond, sterically demanding trisubstituted dihydro- and tetrahydrofuran derivatives were prepared in good overall yields and with high diastereoselectivities (see below).
