21182-47-8

Upstream product

• 111-64-8 n-octanoic acid chloride 
• 150-78-7 1,4-dimethoxybezene 
• 615-94-1 2,5-dihydroxy-1,4-benzoquinone 
• 67820-74-0 2,2,6,6-tetramethylbenzo[1,2-d;4,5-d¹]bis[1,3]dioxole 
• 636-32-8 1,2,4,5-benzenetetrol 
• 1609067-61-9 C₂₀H₃₀O₄ 
• 20491-91-2 2,4,5-trimethoxyphenol 
• 4460-86-0 asaraldehyde 
• 111-83-1 1-bromo-octane 
• 2441-46-5 1,2,4,5-tetramethoxybenzene 
• 21182-43-4 2-Octyl-benzochinon-(1,4) 
• 21182-58-1 2-Hydroxy-5-octanoyloxy-octanophenon 
• 4693-19-0 1-(2,5-dihydroxyphenyl)-1-octanone 
• 1706-69-0 n-octylhydroquinone 

Relevant academic research and scientific papers

Modular synthesis and antiproliferative activity of new dihydro-1H-pyrazolo[1,3-b]pyridine embelin derivatives

A set of new dihydro-1H-pyrazolo[1,3-b]pyridine and pyrazolo[1,3-b]pyridine embelin derivatives was synthesized through a multicomponent reaction from natural embelin, 3-substituted-5-aminopyrazoles and aldehydes. The synthesized compounds were evaluated against three hematologic tumor cell lines, HEL (acute erythroid leukemia), K-562 (chronic myeloid leukemia) and HL-60 (acute myeloid leukemia), and five breast cancer cell lines (SKBR3, MCF-7, MDA-MB-231, BT-549, HS-578T). The primate non-malignant kidney Vero cell line was used as the control of cytotoxicity. From the obtained results, some structure–activity relationships were out-lined. Furthermore, in silico prediction of physicochemical properties and ADME parameters were determined for the derivatives with the best antiproliferative values.

A new family of densely functionalized fused-benzoquinones as potent human protein kinase CK2 inhibitors

A new series of 2-amino-4-phenyl-6-hydroxy-7-alkyl-pyranobenzoquinones was synthesized as ATP-competitive CK2 inhibitors. They were readily synthesized through a three-component Knoevenagel condensation-Michael addition-heterocyclization reaction from ald

The benzoquinone derivatives and their use

The invention provides a p-benzoquinone derivative and an application thereof. The p-benzoquinone derivative has the inhibitory activity on a plasminogen activator inhibitor-1 (PAI-1); on cellular level, the compound can inhibit the transfer ability of HepG2 liver cancer cells; and in-vitro experiments show that the compound has an inhibition effect on formation of fibrin clots. The p-benzoquinone derivative can be used as a medicine for treating tumors and thrombotic diseases.

Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes

5-Lipoxygenase (5-LO) is a potential target for pharmacological intervention with various inflammatory and allergic diseases. Starting from the natural dual 5-LO/microsomal prostaglandin E2 synthase (mPGES)-1 inhibitor embelin (2,5-dihydroxy-3-

Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1)

The natural product embelin was found to have PAI-1 inhibitory activity with the IC50 value of 4.94 μM. Based on the structure of embelin, a series of analogues were designed, synthesized, and evaluated for their ability to inhibit PAI-1. The SAR study on these compounds disclosed that the inhibitory potency largely depended on the hydroxyl groups at C2 and C5, and the length of the alkyl chains at C3 and C6. Compound 11 displayed the best PAI-1 inhibitory potency with the IC50 value of 0.18 μM.

Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein

X-Linked inhibitor of apoptosis protein (XIAP) is a promising molecular target for the design of new anticancer drugs aiming at promoting apoptosis in cancer cells. We have previously identified embelin as an inhibitor of XIAP through computational struct