211820-00-7Relevant academic research and scientific papers
Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
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, (2008/06/13)
This invention concerns heterocyclic derivatives of formula (I) which are useful in inhibiting oxido-squalene cyclase, processes for their preparation and pharmaceutical compositions containing them. The present invention is also concerned with heterocycl
Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pKa
Brown, George R.,Foubister, Alan J.,Johnson, Michael C.,Newcombe, Nicholas J.,Waterson, David,Wells, Stuart L.
, p. 2213 - 2216 (2007/10/03)
Potent inhibition of rat microsomal oxidosqualene cyclase-lanosterol synthase (OSC) was maintained after structural modification of the 4-piperidinopyridine OSC inhibitor series. These novel analogues with a much lower pKa range (5.8-6.7) gave
