211859-75-5

Usage

Uses

Used in Pharmaceutical Industry:
m-PEG10-Tos is used as a linker for drug conjugation, facilitating the attachment of therapeutic agents to improve their solubility, stability, and bioavailability in the body. The tosyl group's reactivity in nucleophilic substitution reactions allows for efficient and specific conjugation processes.
Used in Bioconjugation:
In the field of bioconjugation, m-PEG10-Tos is utilized as a versatile linker to connect biological molecules, such as proteins or peptides, with other molecules like drugs or imaging agents. The hydrophilic PEG spacer not only enhances solubility but also provides a stable and flexible connection between the conjugated entities.
Used in Drug Delivery Systems:
m-PEG10-Tos serves as a key component in the development of drug delivery systems, particularly for targeted therapies. Its hydrophilic nature and the reactivity of the tosyl group enable the creation of smart drug carriers that can release their payload in response to specific stimuli, such as changes in pH or the presence of certain enzymes.
Used in Chemical Synthesis:
In chemical synthesis, m-PEG10-Tos is employed as an intermediate or building block for the creation of complex molecules with specific properties. The tosyl group's leaving ability makes it an ideal candidate for various synthetic routes, including the formation of novel polymers, dendrimers, and other macromolecules with tailored characteristics.

Upstream product

• 6048-68-6 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol 
• 104-15-4 toluene-4-sulfonic acid 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1354521-95-1 28-azido-2,5,8,11,14,17,20,23,26-nonaoxaoctacosane 

Relevant academic research and scientific papers

A metal-free fluorescent probe for selective detection of histidine

A highly selective fluorescent probe has been discovered for the recognition of L-histidine (His) without the need to use a metal cation. Mechanistic studies including 1D and 2D 1H and 13C NMR analyses and DFT calculation have reveal

Phenothiazine derivatives and methods of use thereof

The present disclosure relates to phenothiazine derivatives such as conjugates of phenothiazine compounds, as well as pharmaceutical compositions thereof. The present disclosure also relates to a method of making and the use of such compounds for treating cancer, e.g., a lung cancer, a colon cancer, breast cancer or pancreatic cancer.

Gold(I)-isocyanide and gold(I)-carbene complexes as substrates for the laser decoration of gold onto ceramic surfaces

Gold-isocyanide complexes XAu(RNC) (X = halide, pseudohalide, R = alkyl, aryl) and water soluble gold-carbene complexes XAuC(NHPh)[MeN(CH 2CH2O)nMe] (X = Cl, n = 1-11) have been prepared and evaluated as substrates for the direct laser writing of gold decoration onto ceramics. The Royal Society of Chemistry 2007.

Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in treatment of inflammatory conditions and immune disorders

The present invention provides a compound of formula (I) or a solvate thereof wherein: X is —O— or —NH—; Q is (—CH2—)p, (—CH═CH—)p, (—C≡C—)pwhere p is an integer of from 0 to 4; R1is hydrogen or methyl; R2and R3independently represent O or S n is an integer of 1 to 50; and R is hydrogen or methyl. The present invention also provides pharmaceutical compositions and methods of treatment using the compounds of formula (I). The compounds of the present invention are useful for the prophylaxis and treatment of septic shock, inflammatory conditions and immune disorders.