211876-23-2Relevant academic research and scientific papers
Synthesis of enantiopure substituted aziridines by diastereoselective N- bromocyclization and nucleophile-mediated regioselective opening
Agami, Claude,Amiot, Franck,Couty, Francois,Dechoux, Luc
, p. 5373 - 5374 (1998)
Enantiopure β-substituted aziridines were prepared from (S)- phenylglycinol through a key N-bromocyclizatlon of an unsaturated iminoether. A total control of the regioselectivity was observed during the opening of these aziridines by various nucleophiles (N3-, H2O, EtOH, Me2CuLi).
