21190-16-9

Basic information

• Product Name: ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE
• Synonyms: ethyl 4-amino-1H-imidazole-5-carboxylate;Ethyl-4-aMino-5-iMidazolecarboxyltae;ethyl 5-aMino-1H-iMidazole-4-carboxylate HCL;Ethyl 5-amino-1H-imidazole-4-carboxylate;ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE
• CAS NO: 21190-16-9
• Molecular Formula: C₆H₉N₃O₂
• Molecular Weight: 155.15
• EINECS: 200-258-5
• Product Categories: pharmacetical
• Mol File: 21190-16-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 180-181 °C
• Boiling Point: 391.2 °C at 760 mmHg
• Flash Point: 190.4 °C
• Appearance: /
• Density: 1.318 g/cm³
• Vapor Pressure: 2.5E-06mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 11.66±0.10(Predicted)
• CAS DataBase Reference: ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE(21190-16-9)
• EPA Substance Registry System: ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE(21190-16-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 21190-16-9(Hazardous Substances Data)

Usage

General Description

Ethyl 4-amino-5-imidazolecarboxylate is a chemical compound with the molecular formula C6H8N4O2. It is a white to light yellow crystalline powder that is soluble in water and organic solvents. ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been found to have potential anti-inflammatory and anti-cancer properties and is being studied for its potential use in therapeutic applications. Additionally, it has been used in the development of new drugs for the treatment of various diseases.

InChI:InChI=1/C6H9N3O2/c1-2-11-6(10)4-5(7)9-3-8-4/h3H,2,7H2,1H3,(H,8,9)

Upstream product

• 3849-21-6 ethyl cyanoglyoxylate-2-oxime 
• 64-17-5 ethanol 
• 360-97-4 4-amino-5-imidazolecarboxamide 
• 72-40-2 5-aminoimidazole-4-carboxamide hydrochloride 
• 360-97-4 5-Aminoimidazole-4-carboxamide 
• 72-40-2 5-amino-1H-imidazole-4-carboxamide monohydrochloride 
• 50993-52-7 5-diazoimidazole-4-carboxylic acid ethyl ester 
• 101542-73-8 C₁₀H₁₇N₅O₂ 
• 3473-63-0 formamidine acetic acid 
• 150464-08-7 ethyl 2-amino-2-cyano-acetate*oxalate 
• 6313-33-3 formamidine hydrochloride 
• 32683-02-6 ethyl-2-aminocyano acetate 
• 74478-95-8 5-nitro-1⁽³⁾H-imidazole-4-carboxylic acid ethyl ester 

Downstream Products

• 1191241-58-3 ethyl 3-benzoyl-4-hydroxy-4-trifluoromethyl-1,4-dihydroimidazo[5,1-c][1,2,4]triazine-8-carboxylate 
• 1191241-61-8 ethyl 3-benzoyl-4-hydroxy-4-(1,1,2,2-tetrafluoroethyl)-1,4-dihydroimidazo[5,1-c][1,2,4]triazine-8-carboxylate 
• 1191241-63-0 ethyl 3-benzoyl-4-heptafluoropropyl-4-hydroxy-1,4-dihydroimidazo[5,1-c][1,2,4]triazine-8-carboxylate 
• 1250998-26-5 ethyl 2-chloroimidazo[1,5-a]pyrimidine-8-carboxylate 
• 1431654-63-5 ethyl 2-(2-(trifluoromethyl)phenyl)imidazo[1,5-a]pyrimidine-8-carboxylate 
• 1104807-32-0 ethyl 5-(4-benzoyl-3-hydroxy-2-oxo-5-phenyl-2,5-dihydro-1H-pyrrol-1-yl)-1H-imidazole-4-carboxylate 
• 130890-46-9 1-<(2-Acetoxyethoxy)methyl>-5-(N'-benzoylthiocarbamoyl)amino-4-ethoxycarbonylimidazole 
• 130890-49-2 5-(N'-Benzoyl-S-methylisothiocarbamoyl)amino-4-ethoxycarbonylimidazole 
• 89676-57-3 ethyl 2-<(p-bromophenyl)azo>-4-fluoroimidazole-5-carboxylate 
• 89676-59-5 ethyl 2,4-difluoroimidazole-5-carboxylate 
• 64239-99-2 ethyl 5-amino-1-β-D-arabinofuranosylimidazole-4-carboxylate 

Relevant articles and documents

Genetic incorporation of 4-fluorohistidine into peptides enables selective affinity purification

Due to the lowered pKa of 4-fluorohistidine relative to histidine, peptides and proteins containing this amino acid are potentially endowed with novel properties. We report here the optimized synthesis of 4-fluorohistidine and show that it can efficiently replace histidine in in vitro translation reactions. Moreover, peptides containing 6×-fluorohistidine tags are able to be selectively captured and eluted from nickel resin in the presence of his-tagged protein mixtures.

Ketone-substituted heterocyclic compound and anesthetic effect thereof

The invention discloses a ketone-substituted heterocyclic compound and an anesthetic effect thereof. Specifically provided are a compound represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, or a deuterated derivative thereof. The ketone-substituted heterocyclic compound provided by the invention has a good central nervous system inhibition effect, can generate sedative, hypnotic and/or general anesthesia effects, and can control the epilepsy persistent state; the ketone-substituted heterocyclic compound also has the characteristics of quick response and quick recovery while maintaining excellent anesthetic activity; meanwhile, the ketone-substituted heterocyclic compound has almost no inhibition effect on the adrenal cortex function, has small sideeffects, solves the technical problems in the field, and provides a new choice for clinically screening and/or preparing sedative, hypnotic and/or general anesthesia medicines and medicines for controlling the epilepsy persistent state.

Substituted imidazole formate type derivative and application thereof

The invention discloses a compound shown as a formula I or a stereoisomer thereof or pharmaceutically acceptable salts thereof or a solvate thereof or a prodrug thereof or a metabolic product thereofor a deuterated derivative thereof. The compound is a substituted imidazole formate type derivative with a novel structure and belongs to the field of pharmaceutical chemistry. The invention further discloses application of the substituted imidazole formate type derivative to preparation of drugs with calming, hypnosis and/or anesthetic effects and application of the substituted imidazole formatetype derivative to preparation of drugs capable of controlling status epilepticus. The compound disclosed by the invention has a relatively good inhibition effect on a central nervous system and provides a new choice for clinically screening and/or preparing the drugs with the calming, hypnosis and/or anesthetic effects and capable of controlling the status epilepticus. The formula I is shown in the description.