21190-89-6

Basic information

• Product Name: ETHYL 6-CHLORO-2-PYRIDINECARBOXYLATE
• Synonyms: 6-Chloropyridine-2-carboxylic acid ethyl ester;ethyl 6-chloropyridine-2-carboxylate;2-Pyridinecarboxylic acid, 6-chloro-, ethyl ester
• CAS NO: 21190-89-6
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 21190-89-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 289℃
• Flash Point: 129℃
• Appearance: Pale yellow/Crystalline
• Density: 1.245
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.525
• PKA: -0.89±0.10(Predicted)
• CAS DataBase Reference: ETHYL 6-CHLORO-2-PYRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 6-CHLORO-2-PYRIDINECARBOXYLATE(21190-89-6)
• EPA Substance Registry System: ETHYL 6-CHLORO-2-PYRIDINECARBOXYLATE(21190-89-6)

Safety Data

• Hazardous Substances Data: 21190-89-6(Hazardous Substances Data)

Usage

General Description

ETHYL 6-CHLORO-2-PYRIDINECARBOXYLATE is an organic compound with the chemical formula C9H8ClNO2. It is a pyridine derivative with a chloro substituent at the 6-position and an ethyl ester functional group at the 2-position. This chemical is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is known for its role as an intermediate in the production of various active pharmaceutical ingredients and is also used as a building block in organic synthesis. Additionally, it has potential applications in pesticide and herbicide formulations. ETHYL 6-CHLORO-2-PYRIDINECARBOXYLATE is a colorless to pale yellow liquid with a characteristic odor and is classified as a hazardous substance, requiring proper handling and disposal procedures.

InChI:InChI=1/C8H8ClNO2/c1-2-12-8(11)6-4-3-5-7(9)10-6/h3-5H,2H2,1H3

Upstream product

• 2402-78-0 2,6-dichloropyridine 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 4684-94-0 6-chloropicolinic acid 

Downstream Products

• 482629-92-5 ethyl 6-(3,4,5-trimethoxyphenyl)picolinate 
• 153646-84-5 (6-isopropyl-2-pyridyl)methanol 
• 41337-78-4 Ethyl 6-Ethyl-2-pyridinecarboxylate 
• 1383474-28-9 ethyl 6-vinylpicolinate 
• 1027705-64-1 ethyl 6-[4-({(tert-butoxycarbonyl)[(1R)-1-(1-naphthyl)ethyl]amino}methyl)-3-phenylpiperidin-1-yl]pyridine-2-carboxylate 
• 1012330-84-5 methyl 6-(2-(1-(tert-butyldimethylsilyloxy)-3-(4'-((triethylsilyloxy)methyl)biphenyl-4-yl)propyl)oxazol-5-yl)pyridine-2-carboxylate 
• 1012330-17-4 ethyl 6-(2-(3-(biphenyl-4-yl)-1-(tert-butyldimethylsilyloxy)propyl)oxazol-5-yl)pyridine-2-carboxylate 

Relevant articles and documents

Modular syntheses of star-shaped pyridine, bipyridine, and terpyridine derivatives by employing sonogashira reactions

A simple and flexible synthesis for a series of star-shaped pyridine, bipyridine, and terpyridine derivatives is reported by using a modular approach that combines the use of a ligand, spacer, and core unit. A fairly efficient method to prepare 4′-nonafloxy-functionalized terpyridine derivatives is described. The building blocks that contain the functionalized pyridine, bipyridine, or terpyridine derivatives were linked to different C3-symmetrical core units. In most cases, Sonogashira reactions were employed in the crucial final steps of the synthesis. A star-shaped dodecafluorinated compound was also prepared in a straightforward fashion. A simple procedure for the preparation of partially silylated 1,3,5-triethynylbenzene derivatives is presented, which provides an approach to C2-symmetrical star-shaped compounds that have only one terpyridine and two terphenyl units as "dummy" ligands. The absorption and emission spectra of the fully conjugated C3-symmetrical pyridine derivatives were systematically investigated, and fairly large Stokes shifts were observed.

SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS

Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal

1,4-disubstituted piperazines

The present invention relates to 1,4-disubstituted piperazines of the general formula STR1 wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.