211918-97-7

Basic information

• Product Name: N-[(benzyloxy)carbonyl]-L-valyl-N-[(1R)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide
• CAS NO: 211918-97-7
• Molecular Formula: C₂₂H₃₀FN₃O₇
• Molecular Weight: 467.4879
• Mol File: 211918-97-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 732.4°C at 760 mmHg
• Flash Point: 396.7°C
• Density: 1.214g/cm³
• Vapor Pressure: 2.62E-21mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: N-[(benzyloxy)carbonyl]-L-valyl-N-[(1R)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(benzyloxy)carbonyl]-L-valyl-N-[(1R)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide(211918-97-7)
• EPA Substance Registry System: N-[(benzyloxy)carbonyl]-L-valyl-N-[(1R)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide(211918-97-7)

Safety Data

• Hazardous Substances Data: 211918-97-7(Hazardous Substances Data)

Upstream product

• 294860-44-9 tert-butyl (S)-3-{[(9H-fluoren-9-yl)methoxycarbonyl]amino}-5-bromo-4-oxopentanoate 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 

Relevant articles and documents

An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques

An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. The methodology is based on prior coupling of an aspartate fluoromethyl ketone to a linker and mounting it onto resin-bound methylbenzhydrylamine hydrochloride. Subsequently, by utilising standard Fmoc peptide procedures, a number of short Z-protected peptides were synthesised and assessed as possible inhibitors of the main protease from SARS-CoV-2 (3CLpro).