211992-98-2

Upstream product

• 103946-10-7 methyl 4-O-benzyl-2,6-dideoxy-2-fluoro-α-L-talopyranoside 
• 74-88-4 methyl iodide 

Downstream Products

• 211993-28-1 Acetic acid (2S,3R,4R,5R,6R)-6-((1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-5-fluoro-4-methoxy-2-methyl-tetrahydro-pyran-3-yl ester 

Relevant academic research and scientific papers

Synthesis and antitumor activity of the 7-O-(2,6dideoxy-2-fluoro-α-L- talopyranosyl)daunomycinone derivatives modified at C-3' or C-4'

As a part of a study to exploit anthracycline glycosides effective against resistant tumor cells, the 3'-O-methyl (3), 4'-O-methyl (4), 3'- deoxy (6), 3'-deoxy-3'-fluoro (7), and 3'-deoxy-3'-iodo (8) derivatives of 7- O-(2,6-dideoxy-2-fluoro-α-L-talopyranosyl)daunomycinone have been prepared by coupling suitably protected glycosyl bromides with daunomycinone. The doxorubicin-type analog (5) of 4 was also prepared. Among the compounds prepared, 5 showed the highest antitumor activity. Relationships between chemical structures of the synthetic products and antitumor activities, together with the degree of resistance were discussed.