Cas 21203-30-5,4-imino-3-phenyl-4H-quinolizine-1-carbonitrile

21203-30-5

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Basic information

Product Name: 4-imino-3-phenyl-4H-quinolizine-1-carbonitrile
Synonyms: 4-imino-3-phenyl-4H-quinolizine-1-carbonitrile
CAS NO:21203-30-5
Molecular Formula:
Molecular Weight: 245.283
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4-imino-3-phenyl-4H-quinolizine-1-carbonitrile(CAS DataBase Reference)
NIST Chemistry Reference: 4-imino-3-phenyl-4H-quinolizine-1-carbonitrile(21203-30-5)
EPA Substance Registry System: 4-imino-3-phenyl-4H-quinolizine-1-carbonitrile(21203-30-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 21203-30-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 21203-30-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,0 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21203-30:
(7*2)+(6*1)+(5*2)+(4*0)+(3*3)+(2*3)+(1*0)=45
45 % 10 = 5
So 21203-30-5 is a valid CAS Registry Number.

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21203-30-5Relevant academic research and scientific papers

Ultrafast and reversibly cyclization/cycloreversion of 4-imino-4H-Quinolizine-1-Carbonitrile: A new strategy for fluorescence modulation in pH sensing in living cells

Yang, Tao,Li, Huidong,Cao, Zhixin,Yang, Yang,Zheng, Dasheng,Liu, Pingxian,Peng, Cheng,Schaefer, Henry F.,Luo, Youfu

, (2021/08/16)

Reversible chemically stimulated cyclization/cycloreversion reactions are of great interest and highly demanding for developing molecular switches, such as fluorescent probes. Herein, ultrafast and reversible cyclization/cycloreversion reactions of 4-imino-4H-quinolizine-1-carbonitrile (IMQU) derivatives, induced by H+/OH?, were developed as a new strategy for pH sensing. 1H NMR, HRMS techniques and quantum chemical methods applied to the pH sensing behavior of IMQUs reveal its legitimate mechanism. The IMQU derivatives targeted lysosomes and displayed bright emission, large Stokes shifts, robust fatigue resistance, and superior photostability over commercially available Lyso-Tracker Red. A good correlation was found between pKa values and natural atomic charges at the C-1 atom of the aromatic substituents, which should enable rational tuning of the pKa values.

Preparation and application of novel quinolizine pH fluorescence molecular probe

-

, (2018/04/03)

The invention discloses a novel quinolizine pH fluorescence molecular probe which has brand-new action mechanism as shown in the specification, wherein a skeleton structure is 4H-quinolizine-4-imine as shown in the compound in the formula II, C-N bond in

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