21203-88-3 Usage
Description
Diethyl 4-(4,5-dimethoxy-2-nitrophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate, commonly known as Verapamil, is a calcium channel blocker used in the treatment of high blood pressure, angina, and certain heart rhythm disorders. It functions by relaxing the muscles of the blood vessels and heart, promoting easier blood flow and reducing the heart's workload.
Uses
Used in Cardiovascular Applications:
Verapamil is utilized as an antihypertensive agent to manage high blood pressure by dilating blood vessels and reducing peripheral resistance. It is also used as an antianginal medication to alleviate chest pain caused by insufficient blood supply to the heart muscles.
Used in Cardiac Arrhythmia Prevention:
Verapamil is employed as an off-label treatment for the prevention of certain types of cardiac arrhythmias, helping to maintain a regular heartbeat and prevent abnormal heart rhythms.
Used in Migraines and Cluster Headaches:
Verapamil is used off-label for the treatment of migraines and cluster headaches, providing relief from severe headaches and reducing their frequency.
Available in various forms, Verapamil can be found in tablets, extended-release capsules, and injections for intravenous administration. It should be used under the guidance of a healthcare professional to ensure safety and avoid potential side effects or drug interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 21203-88-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,0 and 3 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21203-88:
(7*2)+(6*1)+(5*2)+(4*0)+(3*3)+(2*8)+(1*8)=63
63 % 10 = 3
So 21203-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2O8/c1-7-30-20(24)17-11(3)22-12(4)18(21(25)31-8-2)19(17)13-9-15(28-5)16(29-6)10-14(13)23(26)27/h9-10,19,22H,7-8H2,1-6H3
21203-88-3Relevant articles and documents
A Novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C21H26N2O8): Microwave-irradiated hantzsch ester synthesis, characterization and molecular crystal
Maru, Minaxi S.,Shah, Manish K.
, p. 217 - 225 (2015)
The novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine was synthesized through multicomponent one pot Hantzsch ester synthesis using 4,5-dimethoxy-2-nitrobenzaldehyde, ethyl 3-oxobutanoate, and ammonium carbonate under microwave irradiation and subsequently characterized by several spectroscopic techniques, i.e., ESI mass, IR, 1H, and 13C NMR along with single crystal X-ray diffraction method. The single crystal of 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C21H26N2O8) was developed in 0.35 × 0.30 × 0.25 mm dimension in methanol. The crystal structure parades only intermolecular hydrogen bonding of the N(2)-H(2A). O(2) type and the boat conformation of the dihydropyridine ring.
