Basic information

Product Name: CALCITONIN, HUMAN
Synonyms: H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2;H-CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 (DISULFIDE BRIDGE: 1-7);CYST-GLY-ASN-LEU-SER-THR-CYST-MET-LEU-GLY-THR-TYR-THR-GLN-AS-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO NH2;CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2;CYS-GLY-ASN-LEU-SER-THR-CYS-MET-LEU-GLY-THR-TYR-THR-GLN-ASP-PHE-ASN-LYS-PHE-HIS-THR-PHE-PRO-GLN-THR-ALA-ILE-GLY-VAL-GLY-ALA-PRO-NH2 HUMAN;CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-NH2 (DISULFIDE BRIDGE: 1-7);CALCITONIN, HUMAN;THYROCALCITONIN HUMAN
CAS NO:21215-62-3
Molecular Formula: C151H226N40O45S3
Molecular Weight: 3417.85
EINECS: 244-276-2
Product Categories: Peptide;Calcitonin and CGRP receptor
Mol File: 21215-62-3.mol

Chemical Properties

Melting Point: N/A
Boiling Point: 3061.8±65.0 °C(Predicted)
Flash Point: N/A
Appearance: /powder
Density: 1.326±0.06 g/cm3(Predicted)
Refractive Index: N/A
Storage Temp.: −20°C
Solubility: N/A
Merck: 13,1642
CAS DataBase Reference: CALCITONIN, HUMAN(CAS DataBase Reference)
NIST Chemistry Reference: CALCITONIN, HUMAN(21215-62-3)
EPA Substance Registry System: CALCITONIN, HUMAN(21215-62-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: XP3560000
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 21215-62-3(Hazardous Substances Data)

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21215-62-3 Usage

Uses

Used in Pharmaceutical Industry:
CALCITONIN, HUMAN is used as a therapeutic agent for the treatment of conditions characterized by abnormally high levels of calcium in the blood, such as hypercalcemia and osteoporosis. It helps to reduce the rate of bone resorption, thereby decreasing the release of calcium from the bones into the bloodstream.
CALCITONIN, HUMAN is also used as a research tool to study its ability to stimulate cyclic adenosine monophosphate (cAMP) production post transfection in mammalian cells. This is achieved by activating the human CALCRL (calcitonin receptor-like receptor gene), receptor activity-modifying protein 1 (RAMP1), and CTR (calcitonin receptor), which are essential for understanding the molecular mechanisms underlying CALCITONIN's actions.
Used in Research and Development:
CALCITONIN, HUMAN serves as an important research tool for studying the regulation of calcium homeostasis and bone metabolism. It is used in various in vitro and in vivo experiments to investigate the effects of CALCITONIN on bone cells, as well as its potential role in the treatment of bone-related disorders.
Brand Name:
CALCITONIN, HUMAN is available under the brand name Calcimar, which is manufactured by Rhone-Poulenc Rorer. This brand is specifically formulated for the treatment of conditions associated with elevated calcium levels in the body.

Biochem/physiol Actions

Calcitonin, also referred to as thyrocalcitonin, is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compared to serum. It acts as a first messenger and hence regulates the the production of cAMP as well as mammalian sperm function. It also facilitates the regulation of different isoforms of adenylyl cyclase.

Check Digit Verification of cas no

The CAS Registry Mumber 21215-62-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,1 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 21215-62:
(7*2)+(6*1)+(5*2)+(4*1)+(3*5)+(2*6)+(1*2)=63
63 % 10 = 3
So 21215-62-3 is a valid CAS Registry Number.

InChI:InChI=1/C151H228N40O45S3/c1-17-75(8)118(144(229)163-67-114(205)183-117(74(6)7)143(228)162-64-112(203)165-77(10)150(235)190-50-29-38-106(190)124(158)209)185-125(210)76(9)166-145(230)120(79(12)194)186-131(216)92(45-47-109(155)200)170-142(227)107-39-30-51-191(107)151(236)103(58-85-35-25-20-26-36-85)180-148(233)122(81(14)196)188-139(224)99(59-87-63-159-71-164-87)176-133(218)96(55-83-31-21-18-22-32-83)174-128(213)90(37-27-28-49-152)168-136(221)101(61-111(157)202)177-134(219)97(56-84-33-23-19-24-34-84)175-137(222)102(62-116(207)208)178-129(214)91(44-46-108(154)199)171-147(232)121(80(13)195)187-138(223)98(57-86-40-42-88(198)43-41-86)179-146(231)119(78(11)193)184-115(206)66-161-127(212)94(53-72(2)3)172-130(215)93(48-52-239-16)169-141(226)105(70-238)182-149(234)123(82(15)197)189-140(225)104(68-192)181-132(217)95(54-73(4)5)173-135(220)100(60-110(156)201)167-113(204)65-160-126(211)89(153)69-237/h18-26,31-36,40-43,63,71-82,89-107,117-123,192-198,237-238H,17,27-30,37-39,44-62,64-70,152-153H2,1-16H3,(H2,154,199)(H2,155,200

21215-62-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name	Calcitonin

1.2 Other means of identification

Product number	-
Other names	CALCITONIN, HUMAN

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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