212192-46-6Relevant academic research and scientific papers
N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists
Egle, Ian,Barriault, Nancy,Bordeleau, Michel,Drage, Jillian,Dube, Laurence,Peragine, Jack,Mazzocco, Lucy,Arora, Jalaj,Jarvie, Keith,Tehim, Ashok
, p. 4847 - 4850 (2007/10/03)
A series of N-(1-benzylpyrrolidin-3-yl)arylbenzamides 8 has been prepared, and their structure-activity relationships studied. Potent ligands selective for human D4 (hD4) over hD2 and α1 have been identified. One example was determined to be an antagonist in a cAMP assay, with an IC50 of 1500 nM. A series of N-(1-benzylpyrrolidin-3-yl)arylbenzamides 8 has been prepared, and their structure-activity relationships studied. Potent ligands selective for human D4 (hD4) over hD2 and α1 have been identified. One example was determined to be an antagonist in a cAMP assay, with an IC50 of 1500 nM.
