212204-36-9

Upstream product

• 101250-72-0 (S)-2-Acetylsulfanylmethyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 6216-63-3 N-Cbz-Prolinol 

Downstream Products

• 1420598-89-5 N-((((2S)-1-benzyloxycarbonylpyrrolidin-2-yl)methyl)sulfonyl)-L-phenylalanine isopropylamide 
• 1420598-91-9 N-(((2S)-pyrrolidin-2-ylmethyl)sulfonyl)-L-phenylalanine ispropylamide 
• 1420598-85-1 N-((((2S)-1-benzoylpyrrolidin-2-yl)methyl)sulfonyl)-L-phenylalanine isopropylamide 
• 1420598-93-1 N-((((2S)-1-(N-tert-butyloxycarbonyl-L-alanyl)pyrrolidin-2-yl)-methyl)sulfonyl)-L-phenylalanine isopropylamide 
• 1420598-87-3 N-((((2S)-1-(N-benzoyl-L-alanyl)pyrrolidin-2-yl )methyl)-sulfonyl)-L-phenylalanine isopropylamide 
• 1454845-63-6 ethyl N-[(S)-N-benzyloxycarbonylpyrrolidine-2-ylmethanesulfonyl]glycinate 
• 1454845-40-9 methyl (S)-N-[(S)-N-benzyloxycarbonylpyrrolidine-2-ylmethanesulfonyl]alaninate 

Relevant academic research and scientific papers

Efficient synthesis of protected sulfonopeptides from N-protected 2-aminoalkyl xanthates and thioacetates

An efficient and convenient method was developed for the synthesis of protected sulfonopeptides via N-chlorosuccimide (NCS)/HCl oxidative chlorination of N-protected 2-aminoalkyl xanthates or thioacetates to the corresponding sulfonyl chlorides followed b

An efficient and facile synthesis of N-Cbz-β-aminoalkanesulfonamides

An efficient method for the synthesis of N-Cbz-β- aminoalkanesulfonamides was described. N-Cbz-β-aminoalkanesulfona-mides were readily prepared in good yields from a variety of amino alcohols, including optically active ones, via N-Cbz protection with ben

Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2

The opioid agonists endomorphins (Tyr-Pro-Trp-Phe-NH2; EM1 and Tyr-Pro-Phe-Phe-NH2; EM2) and morphiceptin (Tyr-Pro-Phe-Pro-NH 2) exhibit an extremely high selectivity for μ-opioid receptor. Here a series of novel EM2 and morphiceptin analogues containing in place of the proline at position 2 the S and R residues of β-homologues of proline (HPro), of 2-pyrrolidinemethanesulphonic acid (HPrs) and of 3- pyrrolidinesulphonic acid (βPrs) have been synthesized and their binding affinity and functional activity have been investigated. The highest μ-receptor affinity is shown by [(S)βPrs2]EM2 analogue (6e) which represents the first example of a β-sulphonamido analogue in the field of opioid peptides.