212208-82-7

Upstream product

• 345-24-4 5-bromo-2,4-difluoronitrobenzene 
• 348-57-2 2,4-difluorobromobenzene 
• 14606-42-9 triphenylsilanethiol 
• 212208-81-6 1,5-difluoro-2-nitro-4-vinylbenzene 

Downstream Products

• 212208-85-0 N-[6-(2,4-Difluorophenoxy)-2,3-dihydrobenzo[b]thiophen-5-yl]methanesulfonamide 
• 212208-84-9 6-(2,4-Difluorophenoxy)-2,3-dihydro-5-nitrobenzo[b]thiophene 
• 212269-88-0 5-Amino-6-(2,4-difluorophenoxy)-2,3-dihydrobenzo[b]thiophene 

Relevant academic research and scientific papers

PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS

Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which X1, X2, L, R3, R4, R5, R6, R6a, R7, R9, R9a, and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

Synthesis of sulfonyl flosulide

The sulfone analogue of the selective cyclooxygenase-2 inhibitor flosulide (1) has been prepared in an eight step synthesis. A key step involves a thiol conjugate addition to form the dihydrobenzothiophene ring system.