212252-91-0 Usage
Uses
Used in Pharmaceutical Development:
D-(R)-3-(3-chloro-4-methoxyphenyl)alanine is utilized as a key component in the development of pharmaceuticals, leveraging its structural similarity to natural amino acids to create novel therapeutic agents. Its unique properties may contribute to the design of drugs with specific targeting or activity profiles.
Used in Peptide and Protein Synthesis:
In the field of biochemistry, D-(R)-3-(3-chloro-4-methoxyphenyl)alanine serves as a building block for the synthesis of complex peptides and proteins. Its incorporation into these biomolecules can alter their function, stability, or interaction with other biological systems, offering a means to engineer proteins with tailored properties for research or therapeutic purposes.
Used in Chemical Research:
D-(R)-3-(3-chloro-4-methoxyphenyl)alanine is also valuable in chemical research, where its distinct stereochemistry and functional groups can be explored for new reactions or as part of innovative synthetic pathways. This can lead to the discovery of new compounds with potential applications across various industries.
Used in Biochemical Studies:
The specific spatial arrangement of atoms in D-(R)-3-(3-chloro-4-methoxyphenyl)alanine, indicated by its (R) designation, makes it an interesting subject for biochemical studies. Researchers can investigate how this stereochemistry affects enzyme interactions, protein folding, and other biological processes, potentially uncovering new insights into the role of chirality in biochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 212252-91-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,2,2,5 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 212252-91:
(8*2)+(7*1)+(6*2)+(5*2)+(4*5)+(3*2)+(2*9)+(1*1)=90
90 % 10 = 0
So 212252-91-0 is a valid CAS Registry Number.
212252-91-0Relevant academic research and scientific papers
Total structures of cryptophycins, potent antitumor depsipeptides from the blue-green alga Nostoc sp. strain GSV 224
Trimurtulu, Golakoti,Ohtani, Ikuko,Patterson, Gregory M. L.,Moore, Richard E.,Corbett, Thomas H.,Valeriote, Frederick A.,Demchik, Lisa
, p. 4729 - 4737 (2007/10/02)
Cryptophycin (A, 1), the major cytotoxin in the blue-green alga (cyanobacterium) Nostoc sp. GSV 224, shows excellent activity against solid tumors implanted in mice. This cyclic depsipeptide had previously been isolated from Nostoc sp. ATCC 53789 as an antifungal agent and its gross structure determined by researchers at Merck. The relative and absolute stereochemistry of this potentially important drug has now been established using a combination of chemical and spectral techniques. Six minor cryptophycins (B-G, 2-7) have also been isolated from GSV 224 and their total structures and cytotoxicities determined. Two types of cryptophycins are present in this alga, the major series possessing a monochlorinated L-O-methyltyrosine unit and the minor series possessing a nonchlorinated D-O-methyltyrosine unit. Structure-activity relationship (SAR) studies of the cryptophycins and several derivatives and degradation products (8-14) are described. Also presented are preliminary in vivo results for cryptophycin A against six solid tumors.
