212322-77-5

Usage

Uses

Used in Pharmaceutical Industry:
N-[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine is used as a key intermediate in the synthesis of Dabigatran (D100090), a nonpeptide direct thrombin inhibitor. N-[[2-[[(4-Cyanophenyl)aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine plays a vital role in the development of anticoagulant medications, which are essential for the prevention and treatment of various thrombotic disorders.

Upstream product

• 211915-84-3 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester 
• 60-29-7 diethyl ether 

Downstream Products

• 1610758-18-3 C₂₈H₃₁N₇O₃*C₇H₈O₃S 
• 1610758-16-1 C₂₆H₂₇N₇O₃*C₇H₈O₃S 
• 211915-00-3 methyl-3-[[[2-[[[4-[amino[[[(hexyloxy)carbonyl]imino]methyl]]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionate 
• 1610758-19-4 C₃₅H₄₃N₇O₅ 
• 212322-47-9 1-methyl-2-[N-(4-cyanophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-[2-(methanesulphonylaminocarbonyl)-ethyl]-amide 

Relevant academic research and scientific papers

Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds and methods of use thereof

The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.

Identification, synthesis, and strategy for the reduction of potential impurities observed in dabigatran etexilate mesylate processes

Synthetic impurities that are present in dabigatran etexilate mesylate were studied, and possible pathways by which these impurities are formed during the manufacturing process were examined. The impurities were monitored by high-performance liquid chromatography, and their structures were determined by mass spectrometry and 1H and 13C NMR. Potential causes for the formation of these impurities are discussed, and strategies to minimize their formation are also described.