21235-67-6

Basic information

• Product Name: Fenfluramine Impurity
• Synonyms: 1-(o-trifluoromethylphenyl)propan-2-one;1-[2-(TRIFLUOROMETHYL)PHENYL]PROPAN-2-ONE
• CAS NO: 21235-67-6
• Molecular Formula: C₁₀H₉F₃O
• Molecular Weight: 202.1730696
• Mol File: 21235-67-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Fenfluramine Impurity(CAS DataBase Reference)
• NIST Chemistry Reference: Fenfluramine Impurity(21235-67-6)
• EPA Substance Registry System: Fenfluramine Impurity(21235-67-6)

Safety Data

• Hazardous Substances Data: 21235-67-6(Hazardous Substances Data)

Usage

Uses

1-[2-(Trifluoromethyl)phenyl]-2-propanone is a reactant used in the synthesis of catechol and bis-catechol and tested for their HIV-1 inhibitory activities.

Upstream product

• 108-22-5 Isopropenyl acetate 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 186581-53-3 diazomethane 
• 3038-48-0 2-(trifluoromethyl)phenylacetic acid 
• 108-24-7 acetic anhydride 
• 444-29-1 2-iodo(trifluoromethyl)benzene 
• 128190-66-9 potassium enolate of acetone 
• 781-89-5 2-Nitro-1-<2-trifluormethyl-phenyl>-propen-(1) 

Downstream Products

• 1197029-75-6 1-(1-(4-(trifluoromethyl)phenyl)ethyl)-1H-pyrrole 
• 21894-66-6 2-(o-Trifluormethylphenyl)-3-butylamin 
• 185557-14-6 6-Methyl-5-(2-trifluoromethyl-phenyl)-2H-pyridazin-3-one 
• 185557-20-4 6-Chloro-3-methyl-4-(2-trifluoromethyl-phenyl)-pyridazine 
• 185557-08-8 5-Hydroxy-5-methyl-4-(2-trifluoromethyl-phenyl)-5H-furan-2-one 
• 21906-06-9 2-(o-Trifluormethylphenyl)-3-butanon 

Relevant articles and documents

UiO-66 microcrystals catalyzed direct arylation of enol acetates and heteroarenes with aryl diazonium salts in water

UiO-66 is a classic Metal–organic framework (MOF) that constructed by zirconium cations and terephthalate with high chemical and thermal stability. Using pristine UiO-66 nanocrystals as the catalysts, the carbon–carbon bond formation based on denitrogenat

Porphyrins as Photoredox Catalysts in Csp2-H Arylations: Batch and Continuous Flow Approaches

We have investigated both batch and continuous flow photoarylations of enol-acetates to yield different α-arylated aldehyde and ketone building blocks by using diazonium salts as the aryl-radical source. Different porphyrins were used as SET photocatalysts, and photophysical as well as electrochemical studies were performed to rationalize the photoredox properties and suggest mechanistic insights. Notably, the most electron-deficient porphyrin (meso-tetra(pentafluorophenyl)porphyrin) shows the best photoactivity as an electron donor in the triplet excited state, which was rationalized by the redox potentials of excited states and the turnover of the porphyrins in the photocatalytic cycle. A two-step continuous protocol and multigram-scale reactions are also presented revealing a robust, cost-competitive, and easy methodology, highlighting the significant potential of porphyrins as SET photocatalysts.

Mass spectrometric investigations on phenylacetic acid derivatives, IV: Loss of ortho-substituents from ionized phenyl-2-propanones upon electron impact

In the gas phase, the phenyl-2-propanone molecules 2a-4a lose upon electron impact chloro-, bromo-, and iodo-radicals specifically at the orthopOsition of the phenyl group giving rise to strong (M-Hal.)+-ions (70/12 eV; 1st and 2nd FFR) of identical structure as confirmed by their MIKE-CAD-spectra. The daughter ions at m/z 133 from o-chlorophenyl-2-propanone (2a) and 2,2-dimethyl-2,3-dihydro[b]furane (11) are structurally similar but not identical (similarity index 99.8). The collisionally activated (2nd FFR) (M-Br.)+-ions from o-bromophenyl-2-propanone (3a) and 1-bromo-1-phenyl-2-propanone (12) produce virtually congruent spectra. The most impOrtant subsequent fragmentation of the (M-Hal-)+-ions from 2a-4a is the loss of CO which incorporates the C-atom of the carbonyl group exclusively (13C labelling). Mechanistic aspects of the fragmentation sequences are discussed (Figs. 5 and 8).