212374-18-0

Usage

Uses

Used in Medical Research:
1,2-Dihydro-1-oxo-5-isoquinolinecarboxylic acid is used as a biomarker for [determining exposure to tobacco smoke] because of its longer half-life compared to nicotine, allowing for its detection over an extended period.
Used in Tobacco Smoke Exposure Studies:
1,2-Dihydro-1-oxo-5-isoquinolinecarboxylic acid is used as a research tool for [studying nicotine dependence and tobacco-related diseases] due to its presence in the urine of tobacco users, making it a reliable indicator of exposure.
Used in Public Health Assessments:
1,2-Dihydro-1-oxo-5-isoquinolinecarboxylic acid is used as an analytical compound for [assessing the impact of passive smoking] on non-smokers, helping to understand the health risks associated with secondhand smoke exposure.

Upstream product

• 90947-07-2 5-cyanoisoquinolin-1-one 
• 212374-17-9 2-((E)-2-Dimethylamino-vinyl)-isophthalonitrile 
• 2317-22-8 2,6-dicyanotoluene 

Relevant academic research and scientific papers

5-benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1- ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)

PARP-2 is a member of the poly(ADP-ribose) polymerase family, with some activities similar to those of PARP-1 but with other distinct roles. Two series of isoquinolin-1-ones were designed, synthesized, and evaluated as selective inhibitors of PARP-2, usin

Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)

Inhibitors of poly(ADP-ribose)polymerase (PARP) inhibit repair of damaged DNA and thus potentiate radiotherapy and chemotherapy of cancer. 3-Substituted benzamides and 5-substituted isoquinolin-1-ones have been synthesised and evaluated for inhibition of PARP. Reduction of 3-(bromoacetyl)benzamide, followed by treatment with base, gave RS-3-oxiranylbenzamide. Reduction of 3-(hydroxyacetyl)benzonitrile with bakers' yeast gave the R-diol which was converted to R-3-(1,2-dihydroxyethyl)benzamide. Similar reduction of 3-(acetoxyacetyl)benzonitrile led towards the S-diol which was converted to its cyclic acetonide. E-2-(2,6-Dicyanophenyl)-N,N-dimethylethenamine was formed by condensation of 2,6-dicyanotoluene with dimethylformamide dimethyl acetal (DMFDMA); cyclisation under acidic conditions afforded 5-cyanoisoquinolin-1-one. Heck coupling of 5-iodoisoquinolin-1-one with propenoic acid formed E-3-(1-oxoisoquinolin-5-yl)propenoic acid. 3-Oxiranylbenzamide, 5-bromoisoquinolin-1-one and 5-iodoisoquinolin-1-one were among the most potent inhibitors of PARP activity in a preliminary screen in vitro. Copyright (C) 1998 Elsevier Science Ltd.