212388-11-9Relevant academic research and scientific papers
An efficient synthesis of N-phosphorylated azadienes, primary (E)-allylamines, and ss-amino-phosphane oxides and -phosphonates from ss-functionalized oxime derivatives
Palacios, Francisco,Aparicio, Domitila,Garcia, Jesus,Rodriguez, Encina
, p. 1413 - 1423 (2007/10/03)
A simple and stereoselective synthesis of primary (E)-allylamines 1 and 1-azadienes 5, 7 is reported. N-Phosphorylated azadienes 5 and 7 are obtained by addition of phosphorus chlorides 3 to unsaturated oximes 2, while azadienes 24 are prepared by olefination reactions of functionalized enamines 20/21. Reduction of azadienes 5, 7, 24 and derivatives 13/14 and 20/21 with hydrides, followed by deprotection of the resulting amines leads to the formation of primary allylamines 1 and ss-aminophosphane oxides 17, phosphonates 18, and phosphonic acid derivatives 19.
