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21242-21-7

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21242-21-7 Usage

General Description

(3-Methyl-pyridin-2-yl)-thiourea is a chemical compound with the molecular formula C8H10N4S. It is a derivative of thiourea, which is a sulfur-containing compound commonly used in organic synthesis and as a starting material for the production of various chemicals. (3-Methyl-pyridin-2-yl)-thiourea has potential applications in the field of medicinal chemistry, as it has been studied for its potential biological activities such as antifungal and antimicrobial properties. Additionally, thiourea derivatives have also been investigated for their potential use as corrosion inhibitors and as starting materials for the synthesis of heterocyclic compounds. Overall, (3-Methyl-pyridin-2-yl)-thiourea is a versatile compound with potential applications in various fields of chemistry and biology.

Check Digit Verification of cas no

The CAS Registry Mumber 21242-21-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,2,4 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 21242-21:
(7*2)+(6*1)+(5*2)+(4*4)+(3*2)+(2*2)+(1*1)=57
57 % 10 = 7
So 21242-21-7 is a valid CAS Registry Number.

21242-21-7 Well-known Company Product Price

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  • Alfa Aesar

  • (H33648)  N-(4-Methyl-2-pyridyl)thiourea, 97%   

  • 21242-21-7

  • 1g

  • 848.0CNY

  • Detail
  • Alfa Aesar

  • (H33648)  N-(4-Methyl-2-pyridyl)thiourea, 97%   

  • 21242-21-7

  • 5g

  • 2832.0CNY

  • Detail

21242-21-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-methylpyridin-2-yl)thiourea

1.2 Other means of identification

Product number -
Other names 4-Methyl-2-pyridyl-thioharnstoff

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:21242-21-7 SDS

21242-21-7Relevant articles and documents

Structural Characterization of Two Polymorphs of 1-(4-Methylpyridin-2-yl)thiourea and Two Derived 2-Aminothiazoles

B?ck, Denise,Beuchel, Andreas,Goddard, Richard,Imming, Peter,Seidel, Rüdiger W.

, p. 394 - 404 (2021)

Abstract: Two polymorphic forms of 1-(4-methylpyridin-2-yl)thiourea (1) and the crystal and molecular structures of the 2-aminothiazoles N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (2) and N-(4-methylpyridin-2-yl)-4-(pyrazin-2-yl)thiazol-2-amine (3), derived from 1 and the respective α-bromoketone via the Hantzsch reaction, are described. Both polymorphic forms 1α (space group P21/c, Z = 4) and 1β (space group P21/n, Z = 8) crystallize in the monoclinic system but exhibit distinctly different intermolecular hydrogen bonding patterns. Compound 2 (orthorhombic, space group Pca21, Z = 8) forms polymeric N–H?N hydrogen-bonded zigzag tapes in the polar crystal structure, with a significant twisting between the thiazole and pyridine rings. In contrast, the crystal structure of 3 (monoclinic, space group P21/c, Z = 4) features nearly planar centrosymmetric N–H?N hydrogen-bonded dimers, which are laterally joined through long C–H?N contacts, affording a π?π stacked layered structure. Graphic Abstract: Two polymorphs of 1-(4-methylpyridin-2-yl)thiourea and the crystal and molecular structures of two 2-aminothiazoles, derived from 1-(4-methylpyridin-2-yl)thiourea and α-bromoketones via Hantzsch reaction, are reported.[Figure not available: see fulltext.]

2-aminothiazoles as therapeutic leads for prion diseases

Gallardo-Godoy, Alejandra,Gever, Joel,Fife, Kimberly L.,Silber, B. Michael,Prusiner, Stanley B.,Renslo, Adam R.

experimental part, p. 1010 - 1021 (2011/04/25)

2-Aminothiazoles are a new class of small molecules with antiprion activity in prion-infected neuroblastoma cell lines (J. Virol. 2010, 84, 3408). We report here structure-activity studies undertaken to improve the potency and physiochemical properties of 2-aminothiazoles, with a particular emphasis on achieving and sustaining high drug concentrations in the brain. The results of this effort include the generation of informative structure-activity relationships (SAR) and the identification of lead compounds that are orally absorbed and achieve high brain concentrations in animals. The new aminothiazole analogue (5-methylpyridin-2-yl)-[4-(3-phenylisoxazol-5-yl)-thiazol-2-yl]-amine (27), for example, exhibited an EC50 of 0.94 μM in prion-infected neuroblastoma cells (ScN2a-cl3) and reached a concentration of ~25 μM in the brains of mice following three days of oral administration in a rodent liquid diet. The studies described herein suggest 2-aminothiazoles as promising new leads in the search for effective therapeutics for prion diseases.

Heterocyclic inhibitors of kinases

-

Page/Page column 13, (2008/06/13)

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

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