212575-01-4Relevant academic research and scientific papers
Oxathiaphospholane approach to the synthesis of oligodeoxyribonucleotides containing stereodefined internucleotide phosphoroselenoate function
Guga, Piotr,Maciaszek, Anna,Stec, Wojciech J.
, p. 3901 - 3904 (2007/10/03)
(Chemical Equation Presented) 5′-O-DMT-deoxyribonucleoside-3′- O(2-selena-4,4-pentamethylene-1,3,2-oxathiaphospholane) monomers, derivatives of dA, dC, dG, and T, can be resolved into pure P-diastereomers by silica gel column chromatography. They have bee
Nucleoside 3'-O-(2-oxo-'spiro'-4.4-pentamethylene-1.3.2- oxathiaphospholane)s: Monomers for stereocontrolled synthesis of oligo(nucleoside phosphorothioate/phosphate)s
Karwowski, Boleslaw,Guga, Piotr,Kobylanska, Anna,Stec, Wojciech J.
, p. 1747 - 1759 (2007/10/03)
Attempts at synthesis of 'chimeric' oligonucleotide constructs (PO/PS- Oligos) possessing phosphate and P-stereodefined phosphorothioate internucleotide linkages via combined phosphoramidite/oxathiaphospholane methods were unsuccessful. Therefore, novel m
Deoxyribonucleoside 3'-O-(2-thio- and 2-oxo-'spiro'-4,4-pentamethylene- 1,3,2-oxathiaphospholane)s: Monomers for stereocontrolled synthesis of oligo(deoxyribonucleoside phosphorothioate)s and chimeric PS/PO oligonucleotides
Stec, Wojciech J.,Karwowski, Boles?aw,Boczkowska, Ma?gorzata,Guga, Piotr,Kozio?kiewicz, Maria,Sochacki, Marek,Wieczorek, Micha? W.,B?aszczyk, Jaros?aw
, p. 7156 - 7167 (2007/10/03)
New monomers, 5'-O-DMT-deoxyribonucleoside 3'-O-(2-thio-'spiro'-4,4- pentamethylene-1,3,2-oxathiaphospholane)s, were prepared and used for the stereocontrolled synthesis of PS-Oligos via the oxathiaphospholane approach. These monomers and their 2-oxo anal
