212626-92-1Relevant academic research and scientific papers
Studies in Acyl C-H activation via aryl and alkyl to acyl "through space" migration of palladium
Kesharwani, Tanay,Verma, Akhilesh K.,Emrich, Daniel,Ward, Jeffrey A.,Larock, Richard C.
supporting information; experimental part, p. 2591 - 2593 (2009/10/23)
Examples of the 1,4-migration of a palladium moiety in aryl- and alkylpalladium intermediates to the acyl position of an aldehyde or formamide have been observed. The resulting acylpalladium intermediate can undergo ester or carbamate formation by reaction with an alcohol; decarbonylation, followed by β hydride elimination to an alkene; reaction with an organomercurial to form an ester; or alkene insertion. Deuterium-labeling studies have been used to confirm the palladium migration mechanism.
